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Tissue research

BPC-157

An experimental gastric peptide fragment studied in preclinical tissue-repair models.

31 connected records31 graded citations0 external identifiers

Research context

An experimental gastric peptide fragment studied in preclinical tissue-repair models.

Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.

Evidence map

Claims linked to original records.

Evidence levels describe study design. They do not by themselves establish safety or effectiveness.

Not yet classified

Zhang H, Shao L, Feng Q, Guo Q, Wang H, Zhang H

Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis.

pubmed
Not yet classified

Luansritisakul C, Chiang MC, Burns SL, Fonseca ACG

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.

pubmed
Not yet classified

Tewari K, Liu TP, Im C, Hamad C, Petrigliano F, Cheung EC, Kremen TJ Jr

Peptide Supplements and Their Therapeutic Applications in Sports Medicine.

pubmed
Not yet classified

Arunim, Dagar M, Solanki M, Sarita, Mishra R, Gulliya S, Bajpai S

Fabrication and characterization of biocompatible BPC-157 based chitosan hydrogel.

pubmed 2026
Not yet classified

Biçer O, Adanir O, Güleryüz Y, Balci EC, Dinçel YM, Yenigün MY, Aydin C, Bayrak BY

Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.

pubmed
Not yet classified

Vukoja I, Vlainic J, Francina M, Barisic I, Zukanovic G, Miskulin I, Kralj L, Popovic Dolic M, Dulcic D, Tubikanec AM, Sikiric S, Krezic I, Kordic M, Beketic Oreskovic L, Oreskovic I, Strbe S, Staresinic B, Pavelic Turudic T, Perovic D, Bilic V, Stancic Rokotov...

Stable pentadecapeptide therapy counteracts gentamicin-induced nephrotoxicity via nitric oxide-system modulation: evidence from a triple nitric oxide-agent approach in rats.

pubmed 2026
Not yet classified

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A, Tomic L, Strbe S, Barisic I, Beketic Oreskovic L, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A,...

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

pubmed
Not yet classified

Mazzarino M, Colpaert T, Deventer K, Van Eenoo P

Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.

pubmed
Clinical trial

This study is a randomized, double-blind, placebo-controlled pilot trial investigating the effects of BPC-157 on tendon healing and functional recovery following arthroscopic rotator cuff repair (aRCR). BPC-157 is a synthetic peptide that has demonstrated promising regenerative and anti-inflammatory effects in preclinical animal models of musculoskeletal...

Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery

clinicaltrials 2026
Clinical trial

This study will evaluate the effects of Parlay Recover peptide gummies (containing Body Protection Compound BPC-157) on markers of inflammation, physical performance, and recovery in physically active adults. Over an 8-week period, 40 participants will consume two gummies daily and complete questionnaires at Baseline, Week...

A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery

clinicaltrials 2026
Clinical trial

Phase I clinical trial in healthy volunteers to study safety and pharmacokinetics of BPC-157, a pentadecapeptide from gastric source.

PCO-02 - Safety and Pharmacokinetics Trial

clinicaltrials 2015
Clinical trial

This randomized, double-blind, placebo-controlled Phase 2 study evaluates whether pentadecapeptide BPC 157 (BPC-157), an investigational peptide, can speed structural healing and functional recovery after an acute grade II hamstring muscle strain. Participants will receive BPC 157 or placebo for 14 days in addition to a...

BPC 157 for Acute Hamstring Muscle Strain Repair

clinicaltrials 2026
Not yet classified

Demirtaş H

BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence.

pubmed
Not yet classified

Moiz A, O'Keefe EL, O'Keefe JH

Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.

pubmed
Not yet classified

Willis J, Vu N

Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.

pubmed
Not yet classified

Demirtaş H · International Journal of Molecular Sciences

BPC 157 in Rodent Ischemia–Reperfusion Injury: A Critical Review of Preclinical Evidence.

pmc 2026
Not yet classified

Moiz A, O'Keefe EL, O'Keefe JH · Missouri medicine

Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.

pmc
Not yet classified

Shah A, Aria F, Gagnier J, Wasserstein D · Orthopaedic Journal of Sports Medicine

Paper 32. Performance & Promises: A Social Media Review of Alleged Indications, Risks and Usage of “Peptides” in Musculoskeletal Health.

pmc 2026
Not yet classified

Yıldırım AK, Demirtaş H, Özer A, Arslan M · Scientific reports

Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury.

pmc
Not yet classified

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM · HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.

pmc 2025
Not yet classified

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A, Tomic L, Strbe S, Barisic I, Beketic Oreskovic L, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A,...

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

pmc
Not yet classified

Jelińska J, Józwiak M, Szeleszczuk Ł, Sikora K, Kamysz W, Kleczkowska P, Gackowski M, Grodner B · International journal of molecular sciences

BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase.

pmc
Not yet classified

Mateescu DM, Gavrilescu DM, Constantinescu FE, Oancea C, Ilie AC, Folescu R, Popa MD, Iurciuc S, Muresan CO, Enache A · Pharmaceutics

BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers.

pmc
Not yet classified

Gordana Zivanovic-Posilovic · Morressier

Pentadecapeptide BPC 157 counteracts the bupivacaine effect on a cell membrane

crossref 2017
Not yet classified

· Wiley

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

crossref 2020
Not yet classified

· Wiley

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

crossref 2020
Not yet classified

· Wiley

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

crossref 2019
Not yet classified

Wstęp Peptyd BPC-157 (body protection compound-157) wykazuje szerokie działanie modulujące w obrębie osi jelitowo-mózgowej (gut–brain axis – GBA), wpływając na funkcje układu nerwowego i przewodu pokarmowego. Dane eksperymentalne wskazują, że może on działać neuroprotekcyjnie, regulować odpowiedź zapalną oraz oddziaływać na nastroje i funkcje poznawcze. Zrozumienie...

BPC-157 and the gut–brain axis: emerging links between cytoprotection and neuroregeneration

crossref 2026
Not yet classified

· Croatian Medical Association

PENTADECAPEPTIDE BPC 157 RESOLVES TOURNIQUET INDUCED ISCHEMIAREPERFUSION INJURY

crossref 2023
Not yet classified

· Elsevier BV

Pentadecapeptide BPC 157 interaction with other systems in gastric protection

crossref 1995
Not yet classified

· Croatian Medical Association

Hepatoprotective effects of BPC-157 - paracetamol overdose

crossref 2023

Connected data hub

Records with source provenance.

Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.

Clinical Trial

4 records
clinicaltrialsAdmin reviewed

Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery

This study is a randomized, double-blind, placebo-controlled pilot trial investigating the effects of BPC-157 on tendon healing and functional recovery following arthroscopic rotator cuff repair (aRCR). BPC-157 is a synthetic peptide that has demonstrated promising regenerative and anti-inflammatory...

NCT078032502026-08-12
clinicaltrialsAdmin reviewed

BPC 157 for Acute Hamstring Muscle Strain Repair

This randomized, double-blind, placebo-controlled Phase 2 study evaluates whether pentadecapeptide BPC 157 (BPC-157), an investigational peptide, can speed structural healing and functional recovery after an acute grade II hamstring muscle strain. Participants will receive BPC 157 or placebo...

NCT074375472026-02-22
clinicaltrialsAdmin reviewed

PCO-02 - Safety and Pharmacokinetics Trial

Phase I clinical trial in healthy volunteers to study safety and pharmacokinetics of BPC-157, a pentadecapeptide from gastric source.

NCT026372842015-12-15
clinicaltrialsAutomated import

A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery

This study will evaluate the effects of Parlay Recover peptide gummies (containing Body Protection Compound BPC-157) on markers of inflammation, physical performance, and recovery in physically active adults. Over an 8-week period, 40 participants will consume two gummies...

NCT077523812026-08-03

Open Access Article

8 records
pmcAutomated import

BPC 157 in Rodent Ischemia–Reperfusion Injury: A Critical Review of Preclinical Evidence.

Demirtaş H · International Journal of Molecular Sciences

PMC136073362026-09-01
pmcAutomated import

Paper 32. Performance & Promises: A Social Media Review of Alleged Indications, Risks and Usage of “Peptides” in Musculoskeletal Health.

Shah A, Aria F, Gagnier J, Wasserstein D · Orthopaedic Journal of Sports Medicine

PMC135304692026-08-01
pmcAutomated import

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM · HSS journal : the musculoskeletal journal of Hospital for Special Surgery

PMC123136052025-11-01
pmcAutomated import

Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.

Moiz A, O'Keefe EL, O'Keefe JH · Missouri medicine

PMC1358500627 Sep 2026
pmcAutomated import

Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury.

Yıldırım AK, Demirtaş H, Özer A, Arslan M · Scientific reports

PMC1344881227 Sep 2026
pmcAutomated import

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A, Tomic L, Strbe S, Barisic I, Beketic Oreskovic L, Kordic M, Tvrdeic A,...

PMC1330545727 Sep 2026
pmcAutomated import

BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase.

Jelińska J, Józwiak M, Szeleszczuk Ł, Sikora K, Kamysz W, Kleczkowska P, Gackowski M, Grodner B · International journal of molecular sciences

PMC1325707227 Sep 2026
pmcAutomated import

BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers.

Mateescu DM, Gavrilescu DM, Constantinescu FE, Oancea C, Ilie AC, Folescu R, Popa MD, Iurciuc S, Muresan CO, Enache A · Pharmaceutics

PMC1321087727 Sep 2026

Publication

11 records
pubmedAutomated import

Fabrication and characterization of biocompatible BPC-157 based chitosan hydrogel.

Arunim, Dagar M, Solanki M, Sarita, Mishra R, Gulliya S, Bajpai S

425553752026-08-01
pubmedAutomated import

Stable pentadecapeptide therapy counteracts gentamicin-induced nephrotoxicity via nitric oxide-system modulation: evidence from a triple nitric oxide-agent approach in rats.

Vukoja I, Vlainic J, Francina M, Barisic I, Zukanovic G, Miskulin I, Kralj L, Popovic Dolic M, Dulcic D, Tubikanec AM, Sikiric S, Krezic I, Kordic M, Beketic Oreskovic L, Oreskovic I, Strbe S, Staresinic B, Pavelic Turudic...

425334602026-06-01
pubmedAutomated import

Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis.

Zhang H, Shao L, Feng Q, Guo Q, Wang H, Zhang H

4266753527 Sep 2026
pubmedAutomated import

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.

Luansritisakul C, Chiang MC, Burns SL, Fonseca ACG

4263586527 Sep 2026
pubmedAutomated import

Peptide Supplements and Their Therapeutic Applications in Sports Medicine.

Tewari K, Liu TP, Im C, Hamad C, Petrigliano F, Cheung EC, Kremen TJ Jr

4257844527 Sep 2026
pubmedAutomated import

Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.

Biçer O, Adanir O, Güleryüz Y, Balci EC, Dinçel YM, Yenigün MY, Aydin C, Bayrak BY

4254292627 Sep 2026
pubmedAutomated import

BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence.

Demirtaş H

4279477127 Sep 2026
pubmedAutomated import

Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.

Moiz A, O'Keefe EL, O'Keefe JH

4275729027 Sep 2026
pubmedAutomated import

Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.

Willis J, Vu N

4275242627 Sep 2026
pubmedAutomated import

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A, Tomic L, Strbe S, Barisic I, Beketic Oreskovic L, Kordic M, Tvrdeic A,...

4235649116 Sep 2026
pubmedAutomated import

Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.

Mazzarino M, Colpaert T, Deventer K, Van Eenoo P

4232873816 Sep 2026

Scholarly Work

8 records
crossrefAutomated import

BPC-157 and the gut–brain axis: emerging links between cytoprotection and neuroregeneration

Wstęp Peptyd BPC-157 (body protection compound-157) wykazuje szerokie działanie modulujące w obrębie osi jelitowo-mózgowej (gut–brain axis – GBA), wpływając na funkcje układu nerwowego i przewodu pokarmowego. Dane eksperymentalne wskazują, że może on działać neuroprotekcyjnie, regulować odpowiedź zapalną oraz...

10.18794/aams/2160862026-01-27
crossrefAutomated import

PENTADECAPEPTIDE BPC 157 RESOLVES TOURNIQUET INDUCED ISCHEMIAREPERFUSION INJURY

· Croatian Medical Association

10.26800/lv-145-supl2-bs082023-04-23
crossrefAutomated import

Hepatoprotective effects of BPC-157 - paracetamol overdose

· Croatian Medical Association

10.26800/lv-145-supl2-bs042023-04-23
crossrefAutomated import

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

· Wiley

10.1002/brb3.1726/v2/review22020-03-12
crossrefAutomated import

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

· Wiley

10.1002/brb3.1726/v2/review12020-02-18
crossrefAutomated import

Review for "The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats"

· Wiley

10.1002/brb3.1726/v1/review12019-09-28
crossrefAutomated import

Pentadecapeptide BPC 157 counteracts the bupivacaine effect on a cell membrane

Gordana Zivanovic-Posilovic · Morressier

10.26226/morressier.58f5b031d462b80296c9d3942017-05-07
crossrefAutomated import

Pentadecapeptide BPC 157 interaction with other systems in gastric protection

· Elsevier BV

10.1016/0016-5085(95)23539-61995-04-01
Responsible use of information

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