Research context
A synthetic tetrapeptide studied in preclinical cellular-ageing models.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Bioregulator research
Epithalon
A synthetic tetrapeptide studied in preclinical cellular-ageing models.
26 connected records26 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
pubmed
Ivko OM, Trofimova SV, Trofimov AV, Sharkovich Z, Mogilev VA
[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].
pubmed 2026
Morozov AV, Khizhkin EA, Svechkina EB, Vinogradova IA, Ilyukha VA, Anisimov VN, Khavinson VKh
Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
pubmed 2015
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Rogava MA, Lazhava TA
[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].
pubmed 2013
Dzhokhadze TA, Buadze TZh, Rubanov KD, Kiriia NA, Lezhava TA
[Genome instability in pulmonary tuberculosis before and after treatment].
pubmed 2013
Korenevsky AV, Milyutina YP, Bukalyov AV, Baranova YP, Vinogradova IA, Arutjunyan AV
[Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].
pubmed 2026
Linkova NS, Khavinson VKh, Chalisova NI, Katanugina AS, Koncevaya EA
Peptidegic stimulation of differentiation of pineal immune cells.
pubmed 2011
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł · International journal of molecular sciences
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
pmc
V. Kh. Khavinson, I. E. Bondarev, A. A. Butyugov · Springer Science and Business Media LLC
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
crossref 2003
N. D. Goncharova, B. Kh. Khavinson, B. A. Lapin · Springer Science and Business Media LLC
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
crossref 2001
D.N. Khamidova, A.V. Popova, V.V. Bezrodnyi, S.E. Mikhtanyuk, E.V. Popova, I.M. Neelov, F. Leermakers · ITMO University
Computer modeling of interaction of lysine dendrimer with epithalon peptides
crossref 2018
V. Kh. Khavinson, N. D. Yakovleva, V. V. Popuchiev, I. M. Kvetnoi, R. P. Manokhina · Springer Science and Business Media LLC
Reparative Effect of Epithalon on Pineal Gland Ultrastructure in γ-Irradiated Rats
crossref 2001
V. Kh. Khavinson, M. I. Razumovsky, S. V. Trofimova, A. M. Razumovskaya · Springer Science and Business Media LLC
Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
crossref 2003
S. V. Mylnikov, N. V. Pavlova, L. V. Barabanova · Pleiades Publishing Ltd
Antimutagenic effects of synthetic epithalon peptide in mice Mus musculus different in hair color
crossref 2012
V. Kh. Khavinson, V. V. Malinin, N. M. Timofeeva, V. V. Egorova, A. A. Nikitina · Springer Science and Business Media LLC
Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats
crossref 2002
V. Kh. Khavinson, I. E. Bondarev, Alexander A. Butyugov · Bulletin of Experimental Biology and Medicine · 24 citations
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
openalex 2003
Sergey V. Anisimov, K. R. Bokheler, V. Kh. Khavinson, Vladimir Nikolaevich Anisimov · Bulletin of Experimental Biology and Medicine · 19 citations
Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology
openalex 2002
Nadezhda D. Goncharova, B. Kh. Khavinson, Boris A. Lapin · Bulletin of Experimental Biology and Medicine · 12 citations
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
openalex 2001
V. Kh. Khavinson, N. D. Yakovleva, В. В. Попучиев, И. М. Кветной, R. P. Manokhina · Bulletin of Experimental Biology and Medicine · 14 citations
Reparative Effect of Epithalon on Pineal Gland Ultrastructure in γ-Irradiated Rats
openalex 2001
Svetlana V. Rosenfeld, E. F. Togo, V. S. Mikheev, Irina G. Popovich, M A Zabezhinskiĭ, V. Kh. Khavinson et al. · Bulletin of Experimental Biology and Medicine · 10 citations
Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice
openalex 2002
V. Kh. Khavinson, V. V. Malinin, Н. М. Тимофеева, V. V. Egorova, Anna A. Nikitina · Bulletin of Experimental Biology and Medicine · 5 citations
Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats
openalex 2002
V. Kh. Khavinson, Vadim V. Yuzhakov, И. М. Кветной, V. V. Malinin, В. В. Попучиев, Natalia K. Fomina · Bulletin of Experimental Biology and Medicine · 5 citations
Immunohistochemical and Morphometric Analysis of Effects of Vilon and Epithalon on Functional Morphology of Radiosensitive Organs
openalex 2001
V. Kh. Khavinson, M. I. Razumovsky, Svetlana Trofimova, A. M. Razumovskaya · Bulletin of Experimental Biology and Medicine · 3 citations
Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
openalex 2003
Human aging constitutes a multifactorial biological process associated with the progressive interaction among genomic instability, epigenetic alterations, mitochondrial dysfunction, inflammaging, immunosenescence, and neuroendocrine deterioration. Over recent decades, advances in molecular geroscience have increased scientific interest in peptide bioregulators due to their potential effects on cellular...
PEPTIDE BIOREGULATORS, AGING AND HUMAN LONGEVITY: EPITHALON, THYMALIN, THYMOGEN, DSIP, VILON AND VESUGEN IN CIRCADIAN BIOLOGY, TELOMERASE REGULATION AND INFLAMMAGING
crossref 2026
Rahman OF, Lee SJ, Seeds WA
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
pubmed
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
pmc
Connected data hub
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Publication
8 recordspubmedAutomated import
[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].
Ivko OM, Trofimova SV, Trofimov AV, Sharkovich Z, Mogilev VA
pubmedAutomated import
[Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].
Korenevsky AV, Milyutina YP, Bukalyov AV, Baranova YP, Vinogradova IA, Arutjunyan AV
pubmedAutomated import
Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
Morozov AV, Khizhkin EA, Svechkina EB, Vinogradova IA, Ilyukha VA, Anisimov VN, Khavinson VKh
pubmedAutomated import
[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Rogava MA, Lazhava TA
pubmedAutomated import
[Genome instability in pulmonary tuberculosis before and after treatment].
Dzhokhadze TA, Buadze TZh, Rubanov KD, Kiriia NA, Lezhava TA
pubmedAutomated import
Peptidegic stimulation of differentiation of pineal immune cells.
Linkova NS, Khavinson VKh, Chalisova NI, Katanugina AS, Koncevaya EA
pubmedAutomated import
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA
pubmedAutomated import
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł
Scholarly Work
8 recordscrossrefAutomated import
PEPTIDE BIOREGULATORS, AGING AND HUMAN LONGEVITY: EPITHALON, THYMALIN, THYMOGEN, DSIP, VILON AND VESUGEN IN CIRCADIAN BIOLOGY, TELOMERASE REGULATION AND INFLAMMAGING
Human aging constitutes a multifactorial biological process associated with the progressive interaction among genomic instability, epigenetic alterations, mitochondrial dysfunction, inflammaging, immunosenescence, and neuroendocrine deterioration. Over recent decades, advances in molecular geroscience have increased scientific interest in peptide bioregulators...
crossrefAutomated import
Computer modeling of interaction of lysine dendrimer with epithalon peptides
D.N. Khamidova, A.V. Popova, V.V. Bezrodnyi, S.E. Mikhtanyuk, E.V. Popova, I.M. Neelov, F. Leermakers · ITMO University
crossrefAutomated import
Antimutagenic effects of synthetic epithalon peptide in mice Mus musculus different in hair color
S. V. Mylnikov, N. V. Pavlova, L. V. Barabanova · Pleiades Publishing Ltd
crossrefAutomated import
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
V. Kh. Khavinson, I. E. Bondarev, A. A. Butyugov · Springer Science and Business Media LLC
crossrefAutomated import
Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
V. Kh. Khavinson, M. I. Razumovsky, S. V. Trofimova, A. M. Razumovskaya · Springer Science and Business Media LLC
crossrefAutomated import
Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats
V. Kh. Khavinson, V. V. Malinin, N. M. Timofeeva, V. V. Egorova, A. A. Nikitina · Springer Science and Business Media LLC
crossrefAutomated import
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
N. D. Goncharova, B. Kh. Khavinson, B. A. Lapin · Springer Science and Business Media LLC
crossrefAutomated import
Reparative Effect of Epithalon on Pineal Gland Ultrastructure in γ-Irradiated Rats
V. Kh. Khavinson, N. D. Yakovleva, V. V. Popuchiev, I. M. Kvetnoi, R. P. Manokhina · Springer Science and Business Media LLC
Article
8 recordsopenalexAutomated import
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
V. Kh. Khavinson, I. E. Bondarev, Alexander A. Butyugov · Bulletin of Experimental Biology and Medicine · 24 citations
openalexAutomated import
Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
V. Kh. Khavinson, M. I. Razumovsky, Svetlana Trofimova, A. M. Razumovskaya · Bulletin of Experimental Biology and Medicine · 3 citations
openalexAutomated import
Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology
Sergey V. Anisimov, K. R. Bokheler, V. Kh. Khavinson, Vladimir Nikolaevich Anisimov · Bulletin of Experimental Biology and Medicine · 19 citations
openalexAutomated import
Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice
Svetlana V. Rosenfeld, E. F. Togo, V. S. Mikheev, Irina G. Popovich, M A Zabezhinskiĭ, V. Kh. Khavinson et al. · Bulletin of Experimental Biology and Medicine · 10 citations
openalexAutomated import
Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats
V. Kh. Khavinson, V. V. Malinin, Н. М. Тимофеева, V. V. Egorova, Anna A. Nikitina · Bulletin of Experimental Biology and Medicine · 5 citations
openalexAutomated import
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
Nadezhda D. Goncharova, B. Kh. Khavinson, Boris A. Lapin · Bulletin of Experimental Biology and Medicine · 12 citations
openalexAutomated import
Immunohistochemical and Morphometric Analysis of Effects of Vilon and Epithalon on Functional Morphology of Radiosensitive Organs
V. Kh. Khavinson, Vadim V. Yuzhakov, И. М. Кветной, V. V. Malinin, В. В. Попучиев, Natalia K. Fomina · Bulletin of Experimental Biology and Medicine · 5 citations
openalexAutomated import
Reparative Effect of Epithalon on Pineal Gland Ultrastructure in γ-Irradiated Rats
V. Kh. Khavinson, N. D. Yakovleva, В. В. Попучиев, И. М. Кветной, R. P. Manokhina · Bulletin of Experimental Biology and Medicine · 14 citations
Open Access Article
2 recordspmcAutomated import
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
pmcAutomated import
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł · International journal of molecular sciences
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