Cellular senescence
An experimental peptide investigated in laboratory models of senescent-cell signalling.
An experimental peptide investigated in laboratory models of senescent-cell signalling.
Evidence map
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting.
Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence.
Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells.
Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.
Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence.
FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting.
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway.
Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Morphological changes in the liver of experimental animals with combined introduction of adribastin and FOXO4-DRI
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes
FOXO4-DRI ALLEVIATES AGE-RELATED TESTOSTERONE SECRETION INSUFFICIENCY VIA TARGETING SENESCENT LEYDIG CELLS IN AGED MICE
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
PAX3/FOXO4 Fusion Gene
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis
FOXO4 peptide targets myofibroblast ameliorates bleomycin‐induced pulmonary fibrosis in mice through ECM‐receptor interaction pathway
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
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Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X, Wang Y · Frontiers in bioengineering and biotechnology
Ning N, Wang C, Gao T, Ma J, Ding M, Zhang F, Liu Q, Zhang W, Gong L · Molecular carcinogenesis
Jing X, Jia S, Teng M, Day BW, Afolayan AJ, Jarzembowski JA, Lin CW, Hessner MJ, Pritchard KA Jr, Naylor S, Konduri GG, Teng RJ · American journal of respiratory cell and molecular biology
Han X, Yuan T, Zhang J, Shi Y, Li D, Dong Y, Fan S · Journal of cellular and molecular medicine
Mateescu DM, Gavrilescu DM, Marinescu AR, Rosca O, Lazureanu VE, Ilie AC, Muresan CO, Enache A · Antioxidants (Basel, Switzerland)
Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T · Nature communications
Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L · Communications biology
Meng J, Li Y, Wan C, Sun Y, Dai X, Huang J, Hu Y, Gao Y, Wu B, Zhang Z, Jiang K, Xu S, Lovell JF, Hu Y, Wu G, Jin H, Yang K · JCI insight
Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X, Wang Y
Ning N, Wang C, Gao T, Ma J, Ding M, Zhang F, Liu Q, Zhang W, Gong L
Alameen AAM, Al-Kuraishy HM, Fawzy MN, Batiha GE
Jing X, Jia S, Teng M, Day BW, Afolayan AJ, Jarzembowski JA, Lin CW, Hessner MJ, Pritchard KA Jr, Naylor S, Konduri GG, Teng RJ
Mateescu DM, Gavrilescu DM, Marinescu AR, Rosca O, Lazureanu VE, Ilie AC, Muresan CO, Enache A
Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T
Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L
Li Y, Zhang C, Cheng H, Lv L, Zhu X, Ma M, Xu Z, He J, Xie Y, Yang X, Liang X, Deng C, Liu G
Objectives Endothelial cell dysfunction during aging is a key driver of vascular aging and related diseases; however, effective strategies to selectively eliminate senescent endothelial cells and restore vascular function remain lacking. FOXO4-DRI, a novel peptide-based intervention, specifically disrupts...
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53 axis as pivotal in maintaining the viability of senescent cells, and that senescent cells can be targeted selectively...
Yu-Xiang Kong, Zhi-Shuai Li, Yuan-Bo Liu, Bo Pan, Xin Fu, Ran Xiao, Li Yan · Springer Science and Business Media LLC
Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Liu · Elsevier BV
Doxorubicin is actively used in scientific practice not only as a chemotherapeutic drug, but also as a senescence inducer due to its mechanism of action, namely, the blocking of mitosis, the development of mitochondrial dysfunction and DNA intercalation,...
Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis. In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of senescent cells that...
Guihua Liu, Xing Yang, Tingting Li · Elsevier BV
· Qeios
Benjamin M. R. Bourgeois, Emil Spreitzer, Daniel Platero-Rochart, Margret Paar, Qishun Zhou, Sinem Usluer et al. · Nature Communications · 18 citations
Yu-Xiang Kong, Zhi-Shuai Li, Yuanbo Liu, Bo Pan, Xin Yuan Fu, Ran Xiao et al. · Communications Biology · 19 citations
Yanqing Li, Chi Zhang, Haicheng Cheng, Linyan Lv, Xinning Zhu, Menghui Ma et al. · Experimental Gerontology · 13 citations
Emmanuelle Born, Larissa Lipskaia, Marielle Breau, Amal Houssaïni, Delphine Beaulieu, Élisabeth Marcos et al. · Circulation · 147 citations
Xiaodan Han, Tong Yuan, Junling Zhang, Yonggang Shi, Deguan Li, Yinping Dong et al. · Journal of Cellular and Molecular Medicine · 38 citations
Jingshu Meng, Yan Li, Chao Min Wan, Yajie Sun, Xiaomeng Dai, Jing Huang et al. · JCI Insight · 124 citations
Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin · Frontiers in Bioengineering and Biotechnology · 56 citations
Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, Jiahui Yao, Min Zhang et al. · Aging · 96 citations
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