Research context
A long-acting IGF-1 analogue for laboratory cell-growth and signalling research.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Growth signalling
IGF-1 LR3
A long-acting IGF-1 analogue for laboratory cell-growth and signalling research.
32 connected records32 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Yavuz E, Sağır MS, Ercan A, Erginer M, Barlas FB, Sakarya D, Kılıç Ş, Ölçeroğlu B, Yardibi H, Kalaycılar İB, Demiröz A
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.
pubmed 2025
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
pubmed
Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
pubmed 2025
Lu Z, Liu N, Huang H, Wang Y, Tu T, Qin X, Wang X, Zhang J, Su X, Tian J, Bai Y, Luo H, Yao B, Zhang H
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
pubmed 2023
White A, Stremming J, Brown LD, Rozance PJ
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
pubmed 2023
Salvi R, Kumar C, Brahmbhatt K, Subedi R, Idicula-Thomas S, Madan T, Biswas B
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
pubmed
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
pubmed
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ · American journal of physiology. Endocrinology and metabolism
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
pmc
Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM · Journal of Alzheimer's disease : JAD
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
pmc 2025
White A, Stremming J, Brown LD, Rozance PJ · Journal of developmental origins of health and disease
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
pmc 2023
Salvi R, Kumar C, Brahmbhatt K, Subedi R, Idicula-Thomas S, Madan T, Biswas B · International journal of molecular sciences
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
pmc
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ · American journal of physiology. Endocrinology and metabolism
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
pmc
Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD · American journal of physiology. Endocrinology and metabolism
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.
pmc
Jonker SS, Giraud GD, Chang EI, Elman MR, Louey S · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.
pmc 2020
F Khamsi · Elsevier BV
In Vivo Infusion With IGF-I Analogue, Long Arg3-Insulin-Like Growth Factor-I (LR3-IGF-I) Enhances Superovulatory Response in Rats
crossref 1997
F Khamsi, S Roberge, A Rouleau, Y Yavas, D.T Armstrong · Elsevier BV
O-179 In vivo infusion with IGF-I analogue, long Arg3-insulin-like growth factor-I (LR3-IGF-I) enhances superovulatory response in rats
crossref 1997
Zequn Lu, Ning Liu, Huoqing Huang, Yuan Wang, Tao Tu, Xing Qin, Xiaolu Wang, Jie Zhang, Xiaoyun Su, Jian Tian, Yingguo Bai, Huiying Luo, Bin Yao, Honglian Zhang · Springer Science and Business Media LLC
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
crossref 2023
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
HIV-1 Protease (I84V) in Complex with PU1 (LR3-46)
crossref 2022
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
HIV-1 Protease WT (NL4-3) in Complex with LR3-68
crossref 2022
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
HIV-1 Protease WT (NL4-3) in Complex with LR3-55
crossref 2022
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
HIV-1 Protease (I84V) in Complex with LR3-48
crossref 2021
AbstractInsulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet...
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
crossref 2023
Nathan C. Sundgren, George D. Giraud, Jess M. Schultz, Michael R. Lasarev, Philip A. Stork, Kent L. R. Thornburg · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 132 citations
Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes
openalex 2003
Alicia White, Jane Stremming, Stephanie R. Wesolowski, Saif I. Al‐Juboori, Evgenia Dobrinskikh, Sean W. Limesand et al. · American Journal of Physiology-Endocrinology and Metabolism · 3 citations
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep
openalex 2024
Zequn Lu, Ning Liu, Huoqing Huang, Yuan Wang, Tao Tu, Xing Qin et al. · Applied Microbiology and Biotechnology · 8 citations
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
openalex 2023
Ersin Yavuz, Melih S. Sagir, Alp Ercan, Merve Erginer, Fırat Barış Barlas, Deniz Sakarya et al. · International Journal of Biological Macromolecules · 3 citations
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration
openalex 2025
Alicia White, Jane Stremming, Laura Davidson Brown, Paul Joseph Rozance · Journal of Developmental Origins of Health and Disease · 1 citations
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
openalex 2023
DG Armstrong, Carlos G. Gutiérrez, Gwen Baxter, A. L. Glazyrin, George E. Mann, Kathryn J. Woad et al. · Journal of Endocrinology · 107 citations
Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles
openalex 2000
Claire Glister, Dionne Tannetta, Nigel P. Groome, PHILIP G. KNIGHT · Biology of Reproduction · 127 citations
Interactions Between Follicle-Stimulating Hormone and Growth Factors in Modulating Secretion of Steroids and Inhibin-Related Peptides by Nonluteinized Bovine Granulosa Cells1
openalex 2001
Julian E. Bailes, Mikhail M. SOLOVIEV · Biomolecules · 133 citations
Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
openalex 2021
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
pubmed 2026
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M · Frontiers in endocrinology
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
pmc 2026
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Open Access Article
8 recordspmcAutomated import
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M · Frontiers in endocrinology
pmcAutomated import
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM · Journal of Alzheimer's disease : JAD
pmcAutomated import
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
White A, Stremming J, Brown LD, Rozance PJ · Journal of developmental origins of health and disease
pmcAutomated import
Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.
Jonker SS, Giraud GD, Chang EI, Elman MR, Louey S · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
pmcAutomated import
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ · American journal of physiology. Endocrinology and metabolism
pmcAutomated import
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
Salvi R, Kumar C, Brahmbhatt K, Subedi R, Idicula-Thomas S, Madan T, Biswas B · International journal of molecular sciences
pmcAutomated import
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ · American journal of physiology. Endocrinology and metabolism
pmcAutomated import
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.
Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD · American journal of physiology. Endocrinology and metabolism
Publication
8 recordspubmedAutomated import
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M
pubmedAutomated import
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.
Yavuz E, Sağır MS, Ercan A, Erginer M, Barlas FB, Sakarya D, Kılıç Ş, Ölçeroğlu B, Yardibi H, Kalaycılar İB, Demiröz A
pubmedAutomated import
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM
pubmedAutomated import
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
Lu Z, Liu N, Huang H, Wang Y, Tu T, Qin X, Wang X, Zhang J, Su X, Tian J, Bai Y, Luo H, Yao B, Zhang H
pubmedAutomated import
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
White A, Stremming J, Brown LD, Rozance PJ
pubmedAutomated import
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ
pubmedAutomated import
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
Salvi R, Kumar C, Brahmbhatt K, Subedi R, Idicula-Thomas S, Madan T, Biswas B
pubmedAutomated import
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ
Article
8 recordsopenalexAutomated import
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration
Ersin Yavuz, Melih S. Sagir, Alp Ercan, Merve Erginer, Fırat Barış Barlas, Deniz Sakarya et al. · International Journal of Biological Macromolecules · 3 citations
openalexAutomated import
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep
Alicia White, Jane Stremming, Stephanie R. Wesolowski, Saif I. Al‐Juboori, Evgenia Dobrinskikh, Sean W. Limesand et al. · American Journal of Physiology-Endocrinology and Metabolism · 3 citations
openalexAutomated import
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
Zequn Lu, Ning Liu, Huoqing Huang, Yuan Wang, Tao Tu, Xing Qin et al. · Applied Microbiology and Biotechnology · 8 citations
openalexAutomated import
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
Alicia White, Jane Stremming, Laura Davidson Brown, Paul Joseph Rozance · Journal of Developmental Origins of Health and Disease · 1 citations
openalexAutomated import
Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
Julian E. Bailes, Mikhail M. SOLOVIEV · Biomolecules · 133 citations
openalexAutomated import
Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes
Nathan C. Sundgren, George D. Giraud, Jess M. Schultz, Michael R. Lasarev, Philip A. Stork, Kent L. R. Thornburg · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 132 citations
openalexAutomated import
Interactions Between Follicle-Stimulating Hormone and Growth Factors in Modulating Secretion of Steroids and Inhibin-Related Peptides by Nonluteinized Bovine Granulosa Cells1
Claire Glister, Dionne Tannetta, Nigel P. Groome, PHILIP G. KNIGHT · Biology of Reproduction · 127 citations
openalexAutomated import
Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles
DG Armstrong, Carlos G. Gutiérrez, Gwen Baxter, A. L. Glazyrin, George E. Mann, Kathryn J. Woad et al. · Journal of Endocrinology · 107 citations
Scholarly Work
8 recordscrossrefAutomated import
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
Zequn Lu, Ning Liu, Huoqing Huang, Yuan Wang, Tao Tu, Xing Qin, Xiaolu Wang, Jie Zhang, Xiaoyun Su, Jian Tian, Yingguo Bai, Huiying Luo, Bin Yao, Honglian Zhang · Springer Science and Business Media LLC
crossrefAutomated import
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
AbstractInsulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in...
crossrefAutomated import
HIV-1 Protease WT (NL4-3) in Complex with LR3-68
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
crossrefAutomated import
HIV-1 Protease (I84V) in Complex with PU1 (LR3-46)
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
crossrefAutomated import
HIV-1 Protease WT (NL4-3) in Complex with LR3-55
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
crossrefAutomated import
HIV-1 Protease (I84V) in Complex with LR3-48
G.J. Lockbaum, C.A. Schiffer · Worldwide Protein Data Bank
crossrefAutomated import
In Vivo Infusion With IGF-I Analogue, Long Arg3-Insulin-Like Growth Factor-I (LR3-IGF-I) Enhances Superovulatory Response in Rats
F Khamsi · Elsevier BV
crossrefAutomated import
O-179 In vivo infusion with IGF-I analogue, long Arg3-insulin-like growth factor-I (LR3-IGF-I) enhances superovulatory response in rats
F Khamsi, S Roberge, A Rouleau, Y Yavas, D.T Armstrong · Elsevier BV
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Recent PubMed records
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.PMID 42395176 · 2026Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.PMID 41015370 · 2025 NovIGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.PMID 39679943 · 2025 Jan 1Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.PMID 39610283 · 2025 JanRecombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.PMID 37261455 · 2023 JulRegistered clinical studies
Reviewed UniProt records
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