Research context
A human cathelicidin peptide studied in antimicrobial and immune-signalling research.
Innate immunity
A human cathelicidin peptide studied in antimicrobial and immune-signalling research.
A human cathelicidin peptide studied in antimicrobial and immune-signalling research.
Evidence map
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.
Cathelicidin LL-37 inhibits angiogenesis and migration in gastric cancer via inhibition of NF-κB/IL-6 signaling.
Full-length brain-derived α-synuclein fibril models reveal fuzzy-coat control of peptide recognition.
Rational hybrid design and computational characterization of PA-Hyb1: a novel peptide inhibitor targeting the MexB efflux pump in Pseudomonas aeruginosa.
Calmodulin-tagging prevents aggregation and facilitates the proteolytic release of the recombinant human cathelicidin LL-37 by accommodating its hydrophobic regions.
Coordination chemistry and antimicrobial activity of LL-37, its C-terminal fragment, and a peptidomimetic analogue.
Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.
Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.
Immune Reconstitution in Tuberculosis Disease
The Effect of Probiotics on the Improvement of Intestinal and Immune Function
Efficacy Study of Vitamin D Supplementation to Meticillin Resistant Staphylococcus Aureus (MRSA) Carriers
Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis
Intratumoral Injections of LL37 for Melanoma
hCAP18 Levels and Vitamin D Deficiency in Chronic Kidney Disease
Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation
Neurogenic Rosacea and Facial Dysesthesia: Neurovascular-Immune Mechanisms and Translational Therapeutic Perspectives.
Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.
LL-37-based oral antimicrobial therapeutics: translational challenges and future directions-a narrative review.
Peri-implant Vitamin D and Cathelicidin (LL-37) Levels
Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis
A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock
Fermented Milk on the Appearance of Common Winter Infectious Diseases
Exploring the Effects of IL-23 Inhibition by Risankizumab on Psoriasis Autoimmunity
Antenatal Vitamin D3 Dose-finding and Safety Study
Vitamin D in Ventilated ICU Patients
Neurogenic Rosacea and Facial Dysesthesia: Neurovascular–Immune Mechanisms and Translational Therapeutic Perspectives.
Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.
LL-37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides.
Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.
Scalp Rosacea: Current Evidence.
Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.
Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.
Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study.
Human LL-37 Structure
Cathelicidin LL-37
LL-37 and citrullinated-LL-37 enhance disparate oxylipins: LL-37-mediated chemokine response is dependent on COX-2 and the P2X <sub>7</sub> receptor in human bronchial epithelial cells
Ll
LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells
Το αντιμικροβιακό πεπτίδιο LL-37 στη στοματική κοιλότητα
Salmonella Membrane Structural Remodeling Increases Resistance to Antimicrobial Peptide LL-37
Single Amino Acid Modulates Antimicrobial Peptide Cooperativity between LL-37 and HNP1
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This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to...
Recent studies have shown that while mouthwashes exhibit antimicrobial properties against bacteria and their products, at the same time showing the cytotoxic effect on living cells in the mouth.29 To the best of our knowledge, there is no...
Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process. In healthy conditions there is a balance between the bacteria...
The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out...
Diabetic foot ulcer (DFU) is a common complication of diabetes with global prevalence of 6.3%. Treatment of diabetic foot ulcer (DFU) is challenging with disappointing outcome. Wound debridement, infection control, pressure relief and revascularization are main pillars of...
The aims of our study were 1) to evaluate levels of gingival crevicular fluid( GCF) human cathelicidin peptide LL-37 and serum vitamin D3 in smoker and non-smoker patients with chronic periodontitis(CP) 2) to determine whether any correlation between...
Observational studies among critically ill patients have shown strong associations between vitamin D deficiency and adverse outcomes, including increased length of stay, infection, and mortality. It is unknown whether vitamin D deficiency contributes directly to adverse outcomes or...
Vitamin D exerts its effects via the Vitamin D Receptor (VDR) present in activated macrophages and induces expression and release of the cathelicidin, LL-37, a human antimicrobial peptide involved in killing of MTB. We aimed to investigate whether...
The human immune system produces a protein called hCAP18 (also known as LL-37 or cathelicidin). This protein is believed to help the body to fight infections. Studies suggest that vitamin D may important in the production of hCAP18....
Shigellosis is one of the major causes of morbidity and mortality in many developing countries. The continued emergence of antibiotic resistant strains has complicated the treatment of shigellosis and has increased the cost of treatment markedly. Antimicrobial peptides...
Tuberculosis is a disease caused by a bacterium (a germ) that can cause illness in any organ of the body, but most frequently causes disease of the lungs. TB is short for tuberculosis. Treating TB requires several months...
Evaluate the effectiveness and safety of Lactobacillus delbrueckii subsp. bulgaricus LB42 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance pathogen clearance and tissue repair and...
Approximately 80 patients affected by moderate to severe psoriasis will be screened for the presence of LL37( and ADAMTSL5 autoreactive T-cells in their blood at Day 0. Patients whose lymphocytes reacted with proliferation to LL37 or ADAMTSL5 will...
Respiratory and gastrointestinal infections are common in children under the age of 4 years, especially after the start of schooling. These conditions are facilitated by a still incomplete functional maturation of the immune system and the anatomical structure...
The goal of this clinical research study is to find the appropriate dose of LL37 that can be given to patients with melanoma. Researchers also want to learn if LL37 can stimulate the immune system to help control...
The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced.
Assess the influence of HP802-247 on biochemical and cellular markers of inflammation in chronic venous leg ulcers
Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (\
The aim with study is to provide adjunctive therapy with vitamin D and phenylbutyrate together with standard anti-tuberculosis treatment to significantly improve clinical recovery among patients with untreated, active pulmonary tuberculosis.
The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid...
The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients. The enormous impact of ICU-related infection demands the need for cost-effective therapies that can be rapidly implemented...
This is a preliminary study of oral vitamin D3 supplementation in pregnant and non-pregnant women of reproductive age in Bangladesh. The primary objective of the study is to identify a dose of vitamin D3 that can safely be...
Cathelicidins are small proteins in the human body that protect against infection. The purpose of this study is to determine if the amount of cathelicidins and other small proteins found in saliva can predict the amount of these...
Pintado-Grima C, Bárcenas O, Tesei G, Thomasen FE, Lindorff-Larsen K, Ventura S
Ravichandran T, B G H, Ganesan N, K SG
Maden S
Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO
J M, Veeraraghavan VP, Govindarajan S
Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P
Luo H, Li S, Du H, Yang W, You L, Mao D
Abdel-Aziem SH
Shibagaki M, Chrisnanto JO, Tefera DA, Kumeta H, Maeda K, Tsukioka K, Ueda W, Hirai F, Kumaki Y, Tsuda S, Arai T, Aizawa T
Szarszoń K, Luszawska M, Jewgiński M, Janek T, Latajka R, Bellotti D, Wątły J
Selvaraj K, Girish C
Ravichandran T, B G H, Ganesan N, K SG · Bioinformation
Yamaguchi T, Hosokawa K, Mineta T, Hosokawa R, Odawara S, Chiba R, Asanuma K, Toyomaki S, Sato M, Takahashi F, Sakurai S, Takahashi K, Nishijima T · PloS one
Maden S · Medicina
Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO · International Journal of Molecular Sciences
Olvera-Rodríguez V, Pampaloni F, Sechi A, Starace MVR · Dermatology and therapy
Narh JK, Casillas-Vega NG, Zarate X · Applied microbiology and biotechnology
Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P · Cell biomaterials
Selvaraj K, Girish C · World journal of gastrointestinal pharmacology and therapeutics
Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human...
Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human...
· Qeios
· Gallaudet University Press
G. Wang · Worldwide Protein Data Bank
Το αντιμικροβιακό πεπτίδιο LL-37 αποτελεί σημαντικό μόριο της φυσικής ανοσίας στο στοματικό περιβάλλον. Σκοπός της διδακτορικής διατριβής ήταν ο προσδιορισμός της σιελικής συγκέντρωσης του αντιμικροβιακού πεπτιδίου LL-37 καθώς και η διερεύνηση παραγόντων που πιθανώς σχετίζονται με αυτήν. Για...
· American Chemical Society (ACS)
· American Chemical Society (ACS)
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