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Innate immunity

LL-37

A human cathelicidin peptide studied in antimicrobial and immune-signalling research.

51 connected records43 graded citations0 external identifiers

Research context

A human cathelicidin peptide studied in antimicrobial and immune-signalling research.

Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.

Evidence map

Claims linked to original records.

Evidence levels describe study design. They do not by themselves establish safety or effectiveness.

Not yet classified

Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P

Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.

pubmed
Not yet classified

Luo H, Li S, Du H, Yang W, You L, Mao D

Cathelicidin LL-37 inhibits angiogenesis and migration in gastric cancer via inhibition of NF-κB/IL-6 signaling.

pubmed
Not yet classified

Pintado-Grima C, Bárcenas O, Tesei G, Thomasen FE, Lindorff-Larsen K, Ventura S

Full-length brain-derived α-synuclein fibril models reveal fuzzy-coat control of peptide recognition.

pubmed 2026
Not yet classified

Abdel-Aziem SH

Rational hybrid design and computational characterization of PA-Hyb1: a novel peptide inhibitor targeting the MexB efflux pump in Pseudomonas aeruginosa.

pubmed
Not yet classified

Shibagaki M, Chrisnanto JO, Tefera DA, Kumeta H, Maeda K, Tsukioka K, Ueda W, Hirai F, Kumaki Y, Tsuda S, Arai T, Aizawa T

Calmodulin-tagging prevents aggregation and facilitates the proteolytic release of the recombinant human cathelicidin LL-37 by accommodating its hydrophobic regions.

pubmed
Not yet classified

Szarszoń K, Luszawska M, Jewgiński M, Janek T, Latajka R, Bellotti D, Wątły J

Coordination chemistry and antimicrobial activity of LL-37, its C-terminal fragment, and a peptidomimetic analogue.

pubmed
Not yet classified

Selvaraj K, Girish C

Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.

pubmed
Not yet classified

Ravichandran T, B G H, Ganesan N, K SG

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.

pubmed 2026
Clinical trial

Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (\

Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.

clinicaltrials 2014
Clinical trial

The aim with study is to provide adjunctive therapy with vitamin D and phenylbutyrate together with standard anti-tuberculosis treatment to significantly improve clinical recovery among patients with untreated, active pulmonary tuberculosis.

Immune Reconstitution in Tuberculosis Disease

clinicaltrials 2012
Clinical trial

Evaluate the effectiveness and safety of Lactobacillus delbrueckii subsp. bulgaricus LB42 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.

The Effect of Probiotics on the Improvement of Intestinal and Immune Function

clinicaltrials 2025
Clinical trial

The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced.

Efficacy Study of Vitamin D Supplementation to Meticillin Resistant Staphylococcus Aureus (MRSA) Carriers

clinicaltrials 2014
Clinical trial

Observational studies among critically ill patients have shown strong associations between vitamin D deficiency and adverse outcomes, including increased length of stay, infection, and mortality. It is unknown whether vitamin D deficiency contributes directly to adverse outcomes or whether it is simply a biomarker of...

Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis

clinicaltrials 2012
Clinical trial

The goal of this clinical research study is to find the appropriate dose of LL37 that can be given to patients with melanoma. Researchers also want to learn if LL37 can stimulate the immune system to help control the disease.

Intratumoral Injections of LL37 for Melanoma

clinicaltrials 2014
Clinical trial

The human immune system produces a protein called hCAP18 (also known as LL-37 or cathelicidin). This protein is believed to help the body to fight infections. Studies suggest that vitamin D may important in the production of hCAP18. This study is designed to test the...

hCAP18 Levels and Vitamin D Deficiency in Chronic Kidney Disease

clinicaltrials 2009
Clinical trial

The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid applied topically will alter the body's immune...

Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation

clinicaltrials 2011
Not yet classified

Maden S

Neurogenic Rosacea and Facial Dysesthesia: Neurovascular-Immune Mechanisms and Translational Therapeutic Perspectives.

pubmed
Not yet classified

Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.

pubmed
Not yet classified

J M, Veeraraghavan VP, Govindarajan S

LL-37-based oral antimicrobial therapeutics: translational challenges and future directions-a narrative review.

pubmed
Clinical trial

This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to determine how vitamin D levels affect these...

Peri-implant Vitamin D and Cathelicidin (LL-37) Levels

clinicaltrials 2025
Clinical trial

Cathelicidins are small proteins in the human body that protect against infection. The purpose of this study is to determine if the amount of cathelicidins and other small proteins found in saliva can predict the amount of these in the skin of people who have...

Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis

clinicaltrials 2006
Clinical trial

Assess the influence of HP802-247 on biochemical and cellular markers of inflammation in chronic venous leg ulcers

A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers

clinicaltrials 2014
Clinical trial

Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance pathogen clearance and tissue repair and reduce death. Our team has completed a...

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock

clinicaltrials 2023
Clinical trial

Respiratory and gastrointestinal infections are common in children under the age of 4 years, especially after the start of schooling. These conditions are facilitated by a still incomplete functional maturation of the immune system and the anatomical structure and function of the respiratory and gastrointestinal...

Fermented Milk on the Appearance of Common Winter Infectious Diseases

clinicaltrials 2015
Clinical trial

Approximately 80 patients affected by moderate to severe psoriasis will be screened for the presence of LL37( and ADAMTSL5 autoreactive T-cells in their blood at Day 0. Patients whose lymphocytes reacted with proliferation to LL37 or ADAMTSL5 will receive SKYRIZI (Risakizumab) at Day 1, week...

Exploring the Effects of IL-23 Inhibition by Risankizumab on Psoriasis Autoimmunity

clinicaltrials 2021
Clinical trial

This is a preliminary study of oral vitamin D3 supplementation in pregnant and non-pregnant women of reproductive age in Bangladesh. The primary objective of the study is to identify a dose of vitamin D3 that can safely be administered during pregnancy to improve the vitamin...

Antenatal Vitamin D3 Dose-finding and Safety Study

clinicaltrials 2009
Clinical trial

The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients. The enormous impact of ICU-related infection demands the need for cost-effective therapies that can be rapidly implemented to improve patient immune response to control...

Vitamin D in Ventilated ICU Patients

clinicaltrials 2011
Not yet classified

Maden S · Medicina

Neurogenic Rosacea and Facial Dysesthesia: Neurovascular–Immune Mechanisms and Translational Therapeutic Perspectives.

pmc 2026
Not yet classified

Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO · International Journal of Molecular Sciences

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.

pmc 2026
Not yet classified

Narh JK, Casillas-Vega NG, Zarate X · Applied microbiology and biotechnology

LL-37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides.

pmc 2024
Not yet classified

Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P · Cell biomaterials

Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.

pmc
Not yet classified

Olvera-Rodríguez V, Pampaloni F, Sechi A, Starace MVR · Dermatology and therapy

Scalp Rosacea: Current Evidence.

pmc 2026
Not yet classified

Selvaraj K, Girish C · World journal of gastrointestinal pharmacology and therapeutics

Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.

pmc
Not yet classified

Ravichandran T, B G H, Ganesan N, K SG · Bioinformation

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.

pmc 2026
Not yet classified

Yamaguchi T, Hosokawa K, Mineta T, Hosokawa R, Odawara S, Chiba R, Asanuma K, Toyomaki S, Sato M, Takahashi F, Sakurai S, Takahashi K, Nishijima T · PloS one

Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study.

pmc 2026
Not yet classified

G. Wang · Worldwide Protein Data Bank

Human LL-37 Structure

crossref 2008
Not yet classified

Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human cathelicidin CHDP, LL-37, can enhance the expression...

LL-37 and citrullinated-LL-37 enhance disparate oxylipins: LL-37-mediated chemokine response is dependent on COX-2 and the P2X <sub>7</sub> receptor in human bronchial epithelial cells

crossref 2025
Not yet classified

Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human cathelicidin CHDP, LL-37, can enhance the expression...

LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells

crossref 2026
Not yet classified

Το αντιμικροβιακό πεπτίδιο LL-37 αποτελεί σημαντικό μόριο της φυσικής ανοσίας στο στοματικό περιβάλλον. Σκοπός της διδακτορικής διατριβής ήταν ο προσδιορισμός της σιελικής συγκέντρωσης του αντιμικροβιακού πεπτιδίου LL-37 καθώς και η διερεύνηση παραγόντων που πιθανώς σχετίζονται με αυτήν. Για το λόγο αυτό, έγινε λήψη ολικού σάλιου...

Το αντιμικροβιακό πεπτίδιο LL-37 στη στοματική κοιλότητα

crossref
Not yet classified

· American Chemical Society (ACS)

Salmonella Membrane Structural Remodeling Increases Resistance to Antimicrobial Peptide LL-37

crossref
Not yet classified

· American Chemical Society (ACS)

Single Amino Acid Modulates Antimicrobial Peptide Cooperativity between LL-37 and HNP1

crossref

Connected data hub

Records with source provenance.

Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.

Clinical Trial

24 records
clinicaltrialsAdmin reviewed

Peri-implant Vitamin D and Cathelicidin (LL-37) Levels

This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to...

NCT068672502025-03-03
clinicaltrialsAdmin reviewed

Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Levels

Recent studies have shown that while mouthwashes exhibit antimicrobial properties against bacteria and their products, at the same time showing the cytotoxic effect on living cells in the mouth.29 To the best of our knowledge, there is no...

NCT049466172021-06-14
clinicaltrialsAdmin reviewed

The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.

Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process. In healthy conditions there is a balance between the bacteria...

NCT044043352020-05-17
clinicaltrialsAdmin reviewed

Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children

The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out...

NCT042925482020-02-28
clinicaltrialsAdmin reviewed

Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot Ulcers

Diabetic foot ulcer (DFU) is a common complication of diabetes with global prevalence of 6.3%. Treatment of diabetic foot ulcer (DFU) is challenging with disappointing outcome. Wound debridement, infection control, pressure relief and revascularization are main pillars of...

NCT040985622019-09-18
clinicaltrialsAdmin reviewed

Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37

The aims of our study were 1) to evaluate levels of gingival crevicular fluid( GCF) human cathelicidin peptide LL-37 and serum vitamin D3 in smoker and non-smoker patients with chronic periodontitis(CP) 2) to determine whether any correlation between...

NCT039232182019-04-17
clinicaltrialsAdmin reviewed

Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis

Observational studies among critically ill patients have shown strong associations between vitamin D deficiency and adverse outcomes, including increased length of stay, infection, and mortality. It is unknown whether vitamin D deficiency contributes directly to adverse outcomes or...

NCT016894412012-09-18
clinicaltrialsAdmin reviewed

Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)

Vitamin D exerts its effects via the Vitamin D Receptor (VDR) present in activated macrophages and induces expression and release of the cathelicidin, LL-37, a human antimicrobial peptide involved in killing of MTB. We aimed to investigate whether...

NCT015800072012-04-17
clinicaltrialsAdmin reviewed

hCAP18 Levels and Vitamin D Deficiency in Chronic Kidney Disease

The human immune system produces a protein called hCAP18 (also known as LL-37 or cathelicidin). This protein is believed to help the body to fight infections. Studies suggest that vitamin D may important in the production of hCAP18....

NCT010263632009-12-02
clinicaltrialsAdmin reviewed

Therapeutic Induction of Endogenous Antibiotics

Shigellosis is one of the major causes of morbidity and mortality in many developing countries. The continued emergence of antibiotic resistant strains has complicated the treatment of shigellosis and has increased the cost of treatment markedly. Antimicrobial peptides...

NCT008009302008-12-02
clinicaltrialsAdmin reviewed

Vitamin D in Active Tuberculosis (TB) Study

Tuberculosis is a disease caused by a bacterium (a germ) that can cause illness in any organ of the body, but most frequently causes disease of the lungs. TB is short for tuberculosis. Treating TB requires several months...

NCT007883202008-11-07
clinicaltrialsAutomated import

The Effect of Probiotics on the Improvement of Intestinal and Immune Function

Evaluate the effectiveness and safety of Lactobacillus delbrueckii subsp. bulgaricus LB42 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.

NCT068734382025-03-03
clinicaltrialsAutomated import

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock

Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance pathogen clearance and tissue repair and...

NCT059692752023-07-12
clinicaltrialsAutomated import

Exploring the Effects of IL-23 Inhibition by Risankizumab on Psoriasis Autoimmunity

Approximately 80 patients affected by moderate to severe psoriasis will be screened for the presence of LL37( and ADAMTSL5 autoreactive T-cells in their blood at Day 0. Patients whose lymphocytes reacted with proliferation to LL37 or ADAMTSL5 will...

NCT047226402021-01-20
clinicaltrialsAutomated import

Fermented Milk on the Appearance of Common Winter Infectious Diseases

Respiratory and gastrointestinal infections are common in children under the age of 4 years, especially after the start of schooling. These conditions are facilitated by a still incomplete functional maturation of the immune system and the anatomical structure...

NCT023676122015-02-12
clinicaltrialsAutomated import

Intratumoral Injections of LL37 for Melanoma

The goal of this clinical research study is to find the appropriate dose of LL37 that can be given to patients with melanoma. Researchers also want to learn if LL37 can stimulate the immune system to help control...

NCT022253662014-08-22
clinicaltrialsAutomated import

Efficacy Study of Vitamin D Supplementation to Meticillin Resistant Staphylococcus Aureus (MRSA) Carriers

The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced.

NCT021784882014-06-12
clinicaltrialsAutomated import

A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers

Assess the influence of HP802-247 on biochemical and cellular markers of inflammation in chronic venous leg ulcers

NCT021540872014-05-28
clinicaltrialsAutomated import

Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.

Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (\

NCT021385912014-04-09
clinicaltrialsAutomated import

Immune Reconstitution in Tuberculosis Disease

The aim with study is to provide adjunctive therapy with vitamin D and phenylbutyrate together with standard anti-tuberculosis treatment to significantly improve clinical recovery among patients with untreated, active pulmonary tuberculosis.

NCT016984762012-09-25
clinicaltrialsAutomated import

Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation

The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid...

NCT013982802011-07-19
clinicaltrialsAutomated import

Vitamin D in Ventilated ICU Patients

The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients. The enormous impact of ICU-related infection demands the need for cost-effective therapies that can be rapidly implemented...

NCT013729952011-06-13
clinicaltrialsAutomated import

Antenatal Vitamin D3 Dose-finding and Safety Study

This is a preliminary study of oral vitamin D3 supplementation in pregnant and non-pregnant women of reproductive age in Bangladesh. The primary objective of the study is to identify a dose of vitamin D3 that can safely be...

NCT009386002009-07-13
clinicaltrialsAutomated import

Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis

Cathelicidins are small proteins in the human body that protect against infection. The purpose of this study is to determine if the amount of cathelicidins and other small proteins found in saliva can predict the amount of these...

NCT004079792006-12-04

Publication

11 records
pubmedAutomated import

Full-length brain-derived α-synuclein fibril models reveal fuzzy-coat control of peptide recognition.

Pintado-Grima C, Bárcenas O, Tesei G, Thomasen FE, Lindorff-Larsen K, Ventura S

427420502026-10-01
pubmedAutomated import

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.

Ravichandran T, B G H, Ganesan N, K SG

427016972026-09-17
pubmedAutomated import

Neurogenic Rosacea and Facial Dysesthesia: Neurovascular-Immune Mechanisms and Translational Therapeutic Perspectives.

Maden S

4279629627 Sep 2026
pubmedAutomated import

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.

Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO

4279478327 Sep 2026
pubmedAutomated import

LL-37-based oral antimicrobial therapeutics: translational challenges and future directions-a narrative review.

J M, Veeraraghavan VP, Govindarajan S

4276337427 Sep 2026
pubmedAutomated import

Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.

Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P

4274628227 Sep 2026
pubmedAutomated import

Cathelicidin LL-37 inhibits angiogenesis and migration in gastric cancer via inhibition of NF-κB/IL-6 signaling.

Luo H, Li S, Du H, Yang W, You L, Mao D

4274558127 Sep 2026
pubmedAutomated import

Rational hybrid design and computational characterization of PA-Hyb1: a novel peptide inhibitor targeting the MexB efflux pump in Pseudomonas aeruginosa.

Abdel-Aziem SH

4273077727 Sep 2026
pubmedAutomated import

Calmodulin-tagging prevents aggregation and facilitates the proteolytic release of the recombinant human cathelicidin LL-37 by accommodating its hydrophobic regions.

Shibagaki M, Chrisnanto JO, Tefera DA, Kumeta H, Maeda K, Tsukioka K, Ueda W, Hirai F, Kumaki Y, Tsuda S, Arai T, Aizawa T

4272766427 Sep 2026
pubmedAutomated import

Coordination chemistry and antimicrobial activity of LL-37, its C-terminal fragment, and a peptidomimetic analogue.

Szarszoń K, Luszawska M, Jewgiński M, Janek T, Latajka R, Bellotti D, Wątły J

4270824816 Sep 2026
pubmedAutomated import

Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.

Selvaraj K, Girish C

4270780516 Sep 2026

Open Access Article

8 records
pmcAutomated import

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.

Ravichandran T, B G H, Ganesan N, K SG · Bioinformation

PMC135458702026-09-27
pmcAutomated import

Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study.

Yamaguchi T, Hosokawa K, Mineta T, Hosokawa R, Odawara S, Chiba R, Asanuma K, Toyomaki S, Sato M, Takahashi F, Sakurai S, Takahashi K, Nishijima T · PloS one

PMC135375482026-09-27
pmcAutomated import

Neurogenic Rosacea and Facial Dysesthesia: Neurovascular–Immune Mechanisms and Translational Therapeutic Perspectives.

Maden S · Medicina

PMC136097642026-09-01
pmcAutomated import

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.

Voronko OE, Novikova VS, Klychkova OO, Markina MP, Lee AA, Kashirskikh DA, Khotina VA, Gasanov VAO · International Journal of Molecular Sciences

PMC136072882026-09-01
pmcAutomated import

Scalp Rosacea: Current Evidence.

Olvera-Rodríguez V, Pampaloni F, Sechi A, Starace MVR · Dermatology and therapy

PMC135584952026-09-01
pmcAutomated import

LL-37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides.

Narh JK, Casillas-Vega NG, Zarate X · Applied microbiology and biotechnology

PMC107878912024-12-01
pmcAutomated import

Design of a multimodal synthetic peptide antibiotic derived from human cathelicidin.

Kalimuthu S, Der Torossian Torres M, Leung YY, de la Fuente-Nunez C, Neelakantan P · Cell biomaterials

PMC1357652627 Sep 2026
pmcAutomated import

Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy.

Selvaraj K, Girish C · World journal of gastrointestinal pharmacology and therapeutics

PMC1354818527 Sep 2026

Scholarly Work

8 records
crossrefAutomated import

LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells

Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human...

10.1186/s12931-026-03493-w2026-01-14
crossrefAutomated import

LL-37 and citrullinated-LL-37 enhance disparate oxylipins: LL-37-mediated chemokine response is dependent on COX-2 and the P2X <sub>7</sub> receptor in human bronchial epithelial cells

Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human...

10.1101/2025.10.30.6856792025-10-31
crossrefAutomated import

Cathelicidin LL-37

· Qeios

10.32388/kzjaco2020-02-02
crossrefAutomated import

Ll

· Gallaudet University Press

10.2307/j.ctv2rh2bx5.132018-09-21
crossrefAutomated import

Human LL-37 Structure

G. Wang · Worldwide Protein Data Bank

10.2210/pdb2k6o/pdb2008-09-23
crossrefAutomated import

Το αντιμικροβιακό πεπτίδιο LL-37 στη στοματική κοιλότητα

Το αντιμικροβιακό πεπτίδιο LL-37 αποτελεί σημαντικό μόριο της φυσικής ανοσίας στο στοματικό περιβάλλον. Σκοπός της διδακτορικής διατριβής ήταν ο προσδιορισμός της σιελικής συγκέντρωσης του αντιμικροβιακού πεπτιδίου LL-37 καθώς και η διερεύνηση παραγόντων που πιθανώς σχετίζονται με αυτήν. Για...

10.12681/eadd/2914727 Sep 2026
crossrefAutomated import

Salmonella Membrane Structural Remodeling Increases Resistance to Antimicrobial Peptide LL-37

· American Chemical Society (ACS)

10.1021/acsinfecdis.9b00066.s00227 Sep 2026
crossrefAutomated import

Single Amino Acid Modulates Antimicrobial Peptide Cooperativity between LL-37 and HNP1

· American Chemical Society (ACS)

10.1021/acs.langmuir.5c04387.s00127 Sep 2026

Live discovery

Latest research signals

Live results from PubMed, ClinicalTrials.gov and UniProt. These may not yet have been reviewed or stored in the Data Hub.

Recent PubMed records

Isotretinoin Alleviates Rosacea-like Inflammation by Partially Involving TET2 Upregulation and JAK2/STAT3 Suppression.PMID 42951126 · 2026 Oct 28A Multifunctional Biomimetic Hydrogel with Antibacterial and Antifibrotic Properties for Scar Minimizing Repair of Infected Skin Wounds.PMID 42946320 · 2026 Oct 27Association of Vitamin D Supplementation with VDR and CAMP Expression and Ulcer Healing in Diabetic Foot Infection Involving Biofilm-Forming Bacteria: An Exploratory Prospective Cohort Study.PMID 42943205 · 2026 Sep 23Association of Porphyromonas gingivalis peptidylarginine deiminase with CitH3, LL-37, and ACPA in periodontitis and rheumatoid arthritis.PMID 42937026 · 2026 Oct 27Antimicrobial Peptoids Show Potent Antifungal Activity against Candidozyma (Candida) auris In Vivo and Broad-Spectrum Activity In Vitro against Other Candida Species.PMID 42917104 · 2026 Oct 9

Registered clinical studies

Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot UlcersNCT04098562 · UNKNOWNChlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva LevelsNCT04946617 · UNKNOWNHigh Dose Preoperative Cholecalciferol Supplementation and Perioperative Vitamin D StatusNCT01689779 · COMPLETED

Reviewed UniProt records

Cathelicidin antimicrobial peptideP49913 · Homo sapiensCathelicidin antimicrobial peptideQ1KLX2 · Pongo pygmaeusCathelicidin antimicrobial peptideQ1KLX7 · Macaca fascicularis
Responsible use of information

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