Research context
A mitochondria-derived peptide studied in metabolism and cellular stress response.
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Mitochondrial research
MOTS-c
A mitochondria-derived peptide studied in metabolism and cellular stress response.
36 connected records36 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Kurian GA
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.
pubmed
Suliman ME, Rahman A, Qureshi AR, Barany P, Stenvinkel P, Kublickiene K, Lindholm B
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
pubmed
Ayubi N, Wibawa JC, Kurnaz M, Komaini A
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.
pubmed
This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment
clinicaltrials 2026
Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes. Ferroptosis has recently emerged as a potential mechanism involved in ischemia-reperfusion injury, while the mitochondrial-derived peptides humanin and MOTS-c are...
Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
clinicaltrials 2026
Suliman ME, Rahman A, Qureshi AR, Barany P, Stenvinkel P, Kublickiene K, Lindholm B · Antioxidants (Basel, Switzerland)
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
pmc
Horwath O, Corell L, Wan J, Hjalmarsson E, Starck J, Reitzner SM, Norrbom J, Fernandez-Gonzalo R, Kvist O, Cohen P, von Walden F, Edman S · Experimental physiology
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.
pmc 2026
Willis J, Vu N
Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.
pubmed
Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
pubmed
Zhao Z, Chen W, Zheng X, Geng Z, Dai N, Zhang H, Fu B, Fu X
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.
pubmed
Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, Feng Z
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
pubmed 2027
Rice MC, Imun M, Jung SW, Park CY, Kim JS, Lai RW, Barr CR, Son JM, Tor K, Kim E, Lu RJ, Cohen I, Benayoun BA, Lee C
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
pubmed
Li YH, Wang M, Wan K, Li J, Li XF
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.
pubmed 2026
This study was based on a concurrent newborn genetic and hearing screening program in Nantong city. From January 2016 to December 2020, newborn infants were recruited and received combined screening for free, funded in part by the municipal government and research project foundations. The population-based...
Cohort Of DEafness-gene Screening
clinicaltrials 2023
The investigators are doing this study to determine if there are body composition changes after a 12-week exercise program in breast cancer patients and determine what factors contribute to sustained physical activity after the 12-week exercise program intervention.
Exercise Post-Diagnosis of Breast Cancer
clinicaltrials 2019
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed. While standard intermittent fasting allows water intake, Ramadan dry fasting involves total restriction of both food and fluids from dawn...
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
clinicaltrials 2026
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity. Participants are randomized 1:1 to MOTS-c or placebo, receive standardized lifestyle counseling, and are followed for safety through Week 16.
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
clinicaltrials 2026
A. Four groups of patients with type 2 diabetes mellitus with high or very high cardiovascular risk or heart failure with preserved ejection fraction (HFpEF) will be studied before and at 6 and 12 months of treatment: * 60 patients treated with a combination of...
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
clinicaltrials 2019
Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes. The investigators plan to investigate the association of both biofactors with high on-clopidogrel platelet reactivity and cardiovascular mortality in type 2 diabetic patients with Coronary artery disease
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
clinicaltrials 2019
Sun J, Xu B, Wang D, Sui M, Li S, Chen Y, Wu J, Teng S, Pang Q, Hu C
MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.
pubmed
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction. Prior research focused on ototoxic cases has...
Long Term Outcomes After Vestibular Implantation
clinicaltrials 2024
Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO · Scientific reports
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
pmc
Xing L, Lu B, Zhu X, Al Saeedi M, Lerman A, Eirin A, Cohen P, Lerman LO · Inflammation and regeneration
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.
pmc
Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, Feng Z · Bioactive materials
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
pmc 2027
Rice MC, Imun M, Jung SW, Park CY, Kim JS, Lai RW, Barr CR, Son JM, Tor K, Kim E, Lu RJ, Cohen I, Benayoun BA, Lee C · eLife
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
pmc
Li YH, Wang M, Wan K, Li J, Li XF · Frontiers in immunology
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.
pmc 2026
Amado CA, Agüero J, García-Unzueta M, Berja A, Lavín BA, Martín-Audera P · Journal of translational medicine
MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.
pmc
Ali Mérad · PERSEE Program
La peur des mots. Les mots de la peur
crossref 1997
· PERSEE Program
Mots
crossref
· OpenEdition
Les mots de l’écologie
crossref 2019
LES MOTS DE L'ECOLOGIE A partir d'un corpus de livres de vulgarisation scientifique rédigés par des spécialistes, d'une part, et d'ouvrages de diffusion,de l'autre, répartis de 1974 à 1992, on cherche les modes d'entrée du mot « écologie » en politique et ceux du réseau...
Les mots de l'écologie
crossref 1994
· OpenEdition
Mots
crossref
PALABRAS PARA PROTEGER NUESTRO MEDIO AMBIENTE La Cumbre de la Tierra (Rio, junio de 1992), mediante el análisis de una centena de comunicados de prensa, fue la muestra inédita de una gran solidaridad internacional. En cambio, los intereses personates de cada pais revelan discrepancias de...
Des mots pour protéger notre environnement
crossref 1994
À partir d’une interrogation sur les origines sémantiques et communes des mots écologie, éthologie et économie, nous abordons la construction et les évolutions discursives de l’écologie politique telle qu’elle est comprise dans les années 2000 par les Verts français et italiens. Au cœur de cette analyse...
Écologie et environnement : des mots aux discours. Mises en perspective historiques et discursives
crossref 2019
Jean-Charles Bonenfant · Presses de l'Université Laval
«Des mots, des mots, des mots»
crossref 2018
André Langaney · PERSEE Program
Le poids des mots, le choc des idées
crossref 1992
Connected data hub
Records with source provenance.
Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.
Clinical Trial
9 recordsclinicaltrialsAdmin reviewed
Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes. Ferroptosis has recently emerged as a potential mechanism involved in ischemia-reperfusion injury, while...
clinicaltrialsAdmin reviewed
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity. Participants are randomized 1:1 to MOTS-c or placebo, receive standardized lifestyle counseling, and...
clinicaltrialsAutomated import
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed. While standard intermittent fasting allows water intake, Ramadan dry fasting involves total restriction...
clinicaltrialsAutomated import
Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment
This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control...
clinicaltrialsAutomated import
Long Term Outcomes After Vestibular Implantation
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction....
clinicaltrialsAutomated import
Cohort Of DEafness-gene Screening
This study was based on a concurrent newborn genetic and hearing screening program in Nantong city. From January 2016 to December 2020, newborn infants were recruited and received combined screening for free, funded in part by the municipal...
clinicaltrialsAutomated import
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes. The investigators plan to investigate the association of both biofactors with high on-clopidogrel platelet reactivity and cardiovascular mortality in type...
clinicaltrialsAutomated import
Exercise Post-Diagnosis of Breast Cancer
The investigators are doing this study to determine if there are body composition changes after a 12-week exercise program in breast cancer patients and determine what factors contribute to sustained physical activity after the 12-week exercise program intervention.
clinicaltrialsAutomated import
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
A. Four groups of patients with type 2 diabetes mellitus with high or very high cardiovascular risk or heart failure with preserved ejection fraction (HFpEF) will be studied before and at 6 and 12 months of treatment: *...
Open Access Article
8 recordspmcAutomated import
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, Feng Z · Bioactive materials
pmcAutomated import
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.
Li YH, Wang M, Wan K, Li J, Li XF · Frontiers in immunology
pmcAutomated import
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.
Horwath O, Corell L, Wan J, Hjalmarsson E, Starck J, Reitzner SM, Norrbom J, Fernandez-Gonzalo R, Kvist O, Cohen P, von Walden F, Edman S · Experimental physiology
pmcAutomated import
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO · Scientific reports
pmcAutomated import
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.
Xing L, Lu B, Zhu X, Al Saeedi M, Lerman A, Eirin A, Cohen P, Lerman LO · Inflammation and regeneration
pmcAutomated import
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Suliman ME, Rahman A, Qureshi AR, Barany P, Stenvinkel P, Kublickiene K, Lindholm B · Antioxidants (Basel, Switzerland)
pmcAutomated import
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
Rice MC, Imun M, Jung SW, Park CY, Kim JS, Lai RW, Barr CR, Son JM, Tor K, Kim E, Lu RJ, Cohen I, Benayoun BA, Lee C · eLife
pmcAutomated import
MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.
Amado CA, Agüero J, García-Unzueta M, Berja A, Lavín BA, Martín-Audera P · Journal of translational medicine
Publication
10 recordspubmedAutomated import
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, Feng Z
pubmedAutomated import
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.
Li YH, Wang M, Wan K, Li J, Li XF
pubmedAutomated import
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.
Kurian GA
pubmedAutomated import
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO
pubmedAutomated import
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Suliman ME, Rahman A, Qureshi AR, Barany P, Stenvinkel P, Kublickiene K, Lindholm B
pubmedAutomated import
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.
Ayubi N, Wibawa JC, Kurnaz M, Komaini A
pubmedAutomated import
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.
Zhao Z, Chen W, Zheng X, Geng Z, Dai N, Zhang H, Fu B, Fu X
pubmedAutomated import
MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.
Sun J, Xu B, Wang D, Sui M, Li S, Chen Y, Wu J, Teng S, Pang Q, Hu C
pubmedAutomated import
Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.
Willis J, Vu N
pubmedAutomated import
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
Rice MC, Imun M, Jung SW, Park CY, Kim JS, Lai RW, Barr CR, Son JM, Tor K, Kim E, Lu RJ, Cohen I, Benayoun BA, Lee C
Scholarly Work
9 recordscrossrefAutomated import
Les mots de l’écologie
· OpenEdition
crossrefAutomated import
Écologie et environnement : des mots aux discours. Mises en perspective historiques et discursives
À partir d’une interrogation sur les origines sémantiques et communes des mots écologie, éthologie et économie, nous abordons la construction et les évolutions discursives de l’écologie politique telle qu’elle est comprise dans les années 2000 par les Verts français...
crossrefAutomated import
«Des mots, des mots, des mots»
Jean-Charles Bonenfant · Presses de l'Université Laval
crossrefAutomated import
La peur des mots. Les mots de la peur
Ali Mérad · PERSEE Program
crossrefAutomated import
Les mots de l'écologie
LES MOTS DE L'ECOLOGIE A partir d'un corpus de livres de vulgarisation scientifique rédigés par des spécialistes, d'une part, et d'ouvrages de diffusion,de l'autre, répartis de 1974 à 1992, on cherche les modes d'entrée du mot « écologie...
crossrefAutomated import
Des mots pour protéger notre environnement
PALABRAS PARA PROTEGER NUESTRO MEDIO AMBIENTE La Cumbre de la Tierra (Rio, junio de 1992), mediante el análisis de una centena de comunicados de prensa, fue la muestra inédita de una gran solidaridad internacional. En cambio, los intereses...
crossrefAutomated import
Le poids des mots, le choc des idées
André Langaney · PERSEE Program
crossrefAutomated import
Mots
· PERSEE Program
crossrefAutomated import
Mots
· OpenEdition
Live discovery
Latest research signals
Live results from PubMed, ClinicalTrials.gov and UniProt. These may not yet have been reviewed or stored in the Data Hub.
Recent PubMed records
Integrative transcriptomic and computational analysis associates Ms4a6c+ macrophages with fibrosis in radiation proctitis and computationally nominates MOTS-c as a candidate modulator.PMID 42952740 · 2026Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study.PMID 42939841 · 2026 Oct 1MOTS-c attenuates placental vascular endothelial cell apoptosis in intrahepatic cholestasis of pregnancy by inhibiting K33-linked deubiquitination of BACH1.PMID 42934731 · 2026 Jul 29Mots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence.PMID 42918312 · 2026 Oct 23The mitochondrial-derived peptide MOTS-c improves bioenergetics in aging-associated granulosa cells and oocytes.PMID 42895211 · 2026 Oct 1Registered clinical studies
Cohort Of DEafness-gene ScreeningNCT06133946 · ACTIVE_NOT_RECRUITINGThe Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their CombinationNCT03878706 · RECRUITINGExercise Post-Diagnosis of Breast CancerNCT04013568 · COMPLETEDReviewed UniProt records
Mitochondrial-derived peptide MOTS-cA0A0C5B5G6 · Homo sapiensResponsible use of information
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