Cellular metabolism
A central redox cofactor used in cellular-energy and metabolism research; it is not a peptide.
A central redox cofactor used in cellular-energy and metabolism research; it is not a peptide.
Evidence map
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Genomic prospecting and biochemical characterization of a novel thermostable 3-quinuclidinone reductase from hot spring metagenomes for efficient biocatalysis.
Targeted NAD(+) Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions.
Microbiota-mitochondria axis in neurodegenerative disorders and retinal dysfunction: mechanisms and emerging therapeutic opportunities.
Association between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging.
Identification of differentially expressed lncRNAs and candidate ceRNA networks across Mastitis stages in Sahiwal cattle.
Deuterated Multi-Color Probes for Reaction-Resolved Mapping of Intracellular Redox Pathways With Magnetic Resonance.
Boreal and subarctic freshwaters harbour a diversity of jumbophages.
Impaired Photorespiratory Metabolism Underlies the Decline in CO(2) Assimilation Induced by Alternative Oxidase Inhibition in Rumex K-1 Leaves.
Renewal-NAD+: A Study of Oral NAD+ and Its Multi-omic Impact in a Healthy Cohort
The Influence of Daily Strawberry Intake on Vascular Health in Elderly Men
Iron Supplementation in Heart Failure Patients With Anemia: The IRON-HF Study
The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.
A Study of Mirikizumab (LY3074828) in Participants With Active Crohn's Disease
The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients
Analysis of Radiographic Indices in Carpal Tunnel Syndrome
Systemic energy and neuroinflammatory disturbances in a lactacystin-induced rat model of Parkinson's disease.
Ricinine toxicity in susceptible lepidoptera involves perturbations in β-nicotinamide adenine dinucleotide metabolism.
Biallelic Variants in KMO Cause a Novel Form of Congenital NAD Deficiency.
Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals.
Metabolic Engineering of Pseudomonas putida KT2440 for β-Nicotinamide Mononucleotide Biosynthesis from Glucose and Aspartate.
The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma.
Neural Network-Based System for Rapid Diagnostic Decision Support Using FLIM Data: Segmentation and Classification in Liver, Skin, and Pancreatic Tissues.
Sensitizing Colorectal Cancer to PARP Inhibitors: Biomarkers, Mechanisms, and Combination Strategies.
Aztreonam Lysine for Pseudomonas Infection Eradication Study
COMPARISON OF DEXMEDETOMIDINE AND NORMAL SALINE IN NEBULIZATION TO BLUNT HEMODYNAMIC RESPONSE
Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies
Ultrasound Guided Peripheral Venous Cannulation in Patient Undergoing Elective Surgery Under General Anesthesia.
Posterior Segment Intrusion Using Miniplates
Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin
Exercise and Sauna on Blood Pressure and Cardiovascular Health
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Ricinine toxicity in susceptible lepidoptera involves perturbations in β-nicotinamide adenine dinucleotide metabolism.
NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD (+) biosynthesis.
Biallelic Variants in KMO Cause a Novel Form of Congenital NAD Deficiency.
Multi-layered target identification strategy of natural products: Daphnetin targets NQO1 and OPLAH in silicosis alleviation.
Narrative review of intravenous NAD(+) and NAD(+) precursors in wellness and translational medicine.
Cerebrospinal fluid protein elevations in Alzheimer's disease are dissociated from immune cell composition.
Mitochondrial Modulation as a Therapeutic Entry Point in Neurodegeneration.
Resistance to atrial fibrillation domestication and mitochondrial dysfunction in sheep: a potential key role of the TCA cycle and mitochondrial redox state.
Ratiometric NAD+ Sensors Reveal Subcellular NAD+ Modulators
Nicotinamide adenine dinucleotide (NAD+). Formal potential of the NAD+/NAD· couple and NAD· dimerization rate
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NAD+ and NAD(P)+ Nucleosidase
Special Issue | Donne e Regimi: spunti sul caso afghano
Untitled Crossref work
NAD(P)H Oxidase
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
NAD+ and sirtuins in aging and disease
NAD + in aging, metabolism, and neurodegeneration
NAD+ metabolism and its roles in cellular processes during ageing
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Connected data hub
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Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+). Research published by Maussudi et al. 2012 demonstrated that skin NAD+...
The goal of this 5 day interventional study was to investigate the effects on multiple biological molecules (multi-omics) of Bryleos's commercially available oral LathMized™ Nicotinamide adenine dinucleotide (LNAD+) supplement in healthy adults aged 45-75 years. The main question...
Falls are unplanned events resulting in contact with a lower surface. They are common in older adults, affecting one in three individuals over 65 years old. They have serious consequences, ranging from physical injuries (fractures, traumatic brain injury)...
The purpose of this study is to investigate the changes in adult peripheral blood immune cell subpopulations, subpopulations, and cell functional status before and after intervention with Nicotinamide Mononucleotide (Vital NAD ) as NAD+ supplement for a certain...
The purpose of this study is to evaluate the effect of NMN supplementation (250 and 500 mg/day over 38 days) compared to placebo in healthy volunteers with moderate physical activity on muscle recovery, physical capacity, cardiorespiratory recovery, the...
BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.
Studying genetic predisposition in autoimmune neurological diseases could help improve diagnostic accuracy and offer new treatment possibilities
The aim of this study was to compare wrist radiographic indices in patients with idiopathic carpal tunnel syndrome (CTS) with normal cases. The investigators believe that the investigators can contribute to the development of new treatment strategies by...
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
The study is a multi-centre, Open-label, Randomized Controlled, 1:1 trial comparing Prasugrel-based short DAPT (30-45 days) followed by Prasugrel monotherapy versus standard DAPT regimen in STEMI patients in terms of safety and efficacy endpoints. In the subgroup of...
This study evaluates two different techniques for peripheral venous cannulation in operating theatre. Ultrasound guided insertion of peripheral cannula in comparison with conventional approach without any ultrasound guidance.
The overall objective of this proposed trial is to examine the vascular protective effects provided by the daily consumption of 39g of freeze dried strawberry powder (FDSP) for four weeks. The study population will be older men (60-80...
The study aims to investigate the effects of including regular heat therapy when included to exercise. Specifically, participants in the sauna intervention group will undergo 15 minutes of sauna exposure immediately after a 50-minute session of exercise, 3...
The purpose of this study is to evaluate the safety and effectiveness of the study drug Mirikizumab in participants with active Crohn's Disease.
Treating hyperdivergent malocclusion accompanied by open bite could be challenging and may be done by several methods as high pull headgear and posterior bite planes or surgically by maxillary impaction in adults. Nowadays it's the skeletal anchorage system...
Primary purpose: To evaluate the evolution in time of the antiaggregant platelet effect of sertraline (SSRI) compared to placebo in depressive patients with ACS (Acute Coronary Syndrome) and treated as recommended by a double antiplatelet therapy, aspirin and...
This is an open-label, multi-center study in pediatric patients age 3 months to less than 18 years with cystic fibrosis (CF) and newly detected Pseudomonas aeruginosa (PA) pulmonary colonization/infection. All eligible participants will be treated with a 28-day...
The primary purpose of this protocol is to assess the efficacy, tolerability, and safety of MGA031 when administered according to 3 different MGA031 dosing regimens in children and adults with recent-onset (diagnosis within past 12 weeks) type 1...
Anemia has been demonstrated to be a common finding in patients with heart failure (HF). Previous studies in hospitalized patients with HF have found a prevalence of anemia ranging from 15% to 63%. More importantly, anemic patients with...
Li Q, Jin RY, Wen CW, Ma HY, Shao ZM, Wang XY, Dai LS, Hu LF, Deng MJ · Frontiers in physiology
Alangari A, Arif J, Al Qureshah F, Alkhodairy F · Frontiers in aging
Wang L, Ma BY, Jiang SP, Wei ST, Qin XM, Li ZY · Journal of pharmaceutical analysis
Oh MJ, Jang JY, Jeon Y, Kim GC, Lee H, Lee J, Kim JH, Kim H, Kim M, Kwon HK, Lee H, Kim HS · Molecular Oncology
Aceves-Ewing NM, Li-Villarreal N, Li X, Lalani SR, Rosenfeld JA, Petrosyan V, Milosavljevic A, Gaspero A, Lanza DG, Christiansen AE, Koirala A, Kamal AHM, Putluri N, Coarfa C, Tran B, Lorenzi PL, Tan L, Gijavanekar C, Elsea SH,...
Zaic S, König T, Keritam O, Faber V, Seifried K, Silvaieh S, Krajnc N, Wurm R, Parvizi T, Macher S, Rommer P, Leutmezer F, Bsteh G, Stögmann E, Berger T, Zrzavy T · Alzheimer's & dementia (New York,...
Mamala M, Skowron I, Marczuk K, Bujas A, Harasiuk J, Kulbacka J · Cells
Caluori G, Nattel S, Pinson B, Naud P, Beauvoit B, Claverol S, Vaillant F, Charron S, Guilloteau F, Loyer V, Constantin M, Popa M, Belykh A, Rogowsky A, Haeberlin A, Ploux S, Mahamat HA, Dubois R, Guillot B,...
Li Q, Jin RY, Wen CW, Ma HY, Shao ZM, Wang XY, Dai LS, Hu LF, Deng MJ
Samaiya PK, Agrawal A, Kesharwani S, Sathe R, Prajapati SK, Majumdar S
Pandey B, Tyagi C
Niemi M, Karneyeva K, Sundberg LR, Oksanen HM, Laanto E
Khunderyakova NV, Pshenichnikova TV, Malkov AE, Bulgin IV, Khmil NV, Medvedeva VP, Glushkova OV, Lunin SM, Parfenyuk SB, Khrenov MO, Mironova GD
Aceves-Ewing NM, Li-Villarreal N, Li X, Lalani SR, Rosenfeld JA, Petrosyan V, Milosavljevic A, Gaspero A, Lanza DG, Christiansen AE, Koirala A, Kamal AHM, Putluri N, Coarfa C, Tran B, Lorenzi PL, Tan L, Gijavanekar C, Elsea SH,...
AlEissa MM, Nimer RM, AlMalki RH, AlAhmari R, Alsaieedi AA, Alrukhayes M, Saleh N, Albugami RR, AlQurashi RA, Hawsa EA, Shaded MB, Masood A, Almudarra SS, Alfadda AA, Alonazi HH, Assiri AM, Abdel Rahman A
Gao L, Wei L, Wang S, Li J, Liu J, Guo Z, Li ZM, Li Z
Yue C, Huang BH, Qi L, Zhang XD, Li J
Shchechkin I, Rodimova S, Bobrov N, Elagin V, Ermakova P, Mozherov A, Kashina A, Shcheslavskiy V, Zagainov V, Zagaynova E, Kuznetsova D
Elesnawy M, Masood E, Naik A
Lou D, Cui J, Duan J, Zhou B, Wang Y, Wang D, Tan J, Duan H
Zhou Y, Wang Y, Wang X, Yu R, Chen J, Bao J, Zhang C, Zou Q, Xiong G, Liu P, Jin X, Zhang S, Yao S, Yu X
Shida T, Hatanaka S, Kojima N, Osuka Y, Sasai H
Xie G, Khashami F, Luu QS, Chirayil S, Rocha G, Glöggler S
Zhong X, Li S, Zhang L
· Milano University Press
Redazione Rivista NAD · Milano University Press
· Springer International Publishing
Michaela Freemanová · Oxford University Press
· Oxford University Press
Eva Herrmannová · Oxford University Press
Mark A. Jensen, Philip J. Elving · Elsevier BV
· American Chemical Society (ACS)
Anthony J. Covarrubias, Rosalba Perrone, Alessia Grozio, Eric M. Verdin · Nature Reviews Molecular Cell Biology · 1629 citations
Shin‐ichiro Imai, Leonard P. Guarente · Trends in Cell Biology · 1502 citations
Eric M. Verdin · Science · 1337 citations
Carles Cantó, Zachary Gerhart‐Hines, Jérôme N. Feige, Marie Lagouge, Lilia Guadalupe Noriega, Jill C. Milne et al. · Nature · 3304 citations
In Hye Lee, Liu Cao, Raúl Mostoslavsky, David B. Lombard, Jie Liu, Nicholas E. Bruns et al. · Proceedings of the National Academy of Sciences · 1475 citations
Homayoun Vaziri, Scott K. Dessain, Elinor Ng Eaton, Shin‐ichiro Imai, Roy A. Frye, Tej K. Pandita et al. · Cell · 2678 citations
Kathy K. Griendling, Dan C. Sorescu, Masuko Ushio‐Fukai · Circulation Research · 2892 citations
Shin‐ichiro Imai, Christopher M. Armstrong, Matt R. Kaeberlein, Leonard Guarente · Nature · 3535 citations
Live discovery
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