Fitzbio Research HubEducational content only — not medical advice

Metabolic research

SLU-PP-332

An experimental small molecule, not a peptide, studied in preclinical metabolic research.

31 connected records31 graded citations0 external identifiers

Research context

An experimental small molecule, not a peptide, studied in preclinical metabolic research.

Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.

Evidence map

Claims linked to original records.

Evidence levels describe study design. They do not by themselves establish safety or effectiveness.

Not yet classified

B.-A. Hagiu · Elsevier BV

Can SLU-PP-332 be a new drug to prevent COVID-19?

crossref 2024
Not yet classified

Introduction: Estrogen receptor-related orphan receptors ERRα and ERRγ are essential regulators for cardiac metabolism. Mice lacking ERRα and ERRγ develops lethal cardiomyopathy and heart failure. Therefore, activation of ERR is a potential therapeutic intervention for HF treatment. However, no natural or synthetic ERR agonist is...

Abstract 9682: The Cardiac Protective Effects of Novel Synthetic Pan-Estrogen Related Receptor Agonists Slu-pp-332 and Slu-pp-915

crossref 2021
Not yet classified

Rödlistade arter i Sverige 2025 redovisar risken för att enskilda arter av djur, växter, svampar och alger ska försvinna från Sverige. Den är framtagen enligt IUCN:s rödlistningskriterier. I rödlistan bedöms risken att enskilda arter av djur, växter, svampar och alger ska försvinna från Sverige. Bedömningen...

Rödlistade arter i Sverige 2025

crossref 2026
Not yet classified

The global burden of metabolic disorders, including obesity and type 2 diabetes, necessitates innovative therapeutic strategies. SLU-PP-332, a synthetic agonist of estrogen-related receptor α (ERRα), has emerged as a promising exercise mimetic, demonstrating preclinical efficacy in enhancing mitochondrial biogenesis, insulin sensitivity, and energy expenditure. This...

SLU-PP-332 AND RELATED ERRα AGONISTS: A FOCUSED MINIREVIEW OF METABOLIC REGULATION, AND THERAPEUTIC POTENTIAL

crossref 2025
Not yet classified

B. W. Alsanius, S. Khalil, A. Tadesse, A. K. Rosberg, K. J. Bergstrand, R. Hartmann, L. Mogren, M. Alam, M. Grudén, T. Naznin, A. Getahun · Burleigh Dodds Science Publishing

Sustainable systems for integrated fish and vegetable production: new perspectives on aquaponics

crossref 2019
Not yet classified

· Sule Lamido University Kafin Hausa

SLU Journal of Science and Technology

crossref
Not yet classified

This chapter presents an overview of proximal sensing techniques used in practical precision agriculture, with the overall aim of contributing to more sustainable crop production. To provide perspective on the usefulness of crop sensors, the chapter starts with an example of why site-specific crop management...

Developments in proximal crop sensing for precision agriculture

crossref 2025
Not yet classified

Bogdan-Alexandru HAGIU · Medical Hypotheses · 1 citations

Can SLU-PP-332 be a new drug to prevent COVID-19?

openalex 2024
Not yet classified

Tristan Möller, Oliver Krug, Mario Thevis · Rapid Communications in Mass Spectrometry · 1 citations

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

openalex 2026
Not yet classified

Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan D. Welch, Bahaa Elgendy, Lamees Hegazy et al. · ACS Chemical Biology · 43 citations

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

openalex 2023
Not yet classified

Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Scarpa Wilderman, Lei Qi, Andrea Graves et al. · Circulation · 67 citations

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

openalex 2023
Not yet classified

Cyrielle Billon, Emmalie Schoepke, Amer Avdagic, Arindam Chatterjee, Andrew A. Butler, Bahaa Elgendy et al. · Journal of Pharmacology and Experimental Therapeutics · 30 citations

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

openalex 2023
Not yet classified

Xiaoxin X. Wang, Komuraiah Myakala, Andrew E. Libby, Ewa Krawczyk, Julia Panov, Bryce A. Jones et al. · American Journal Of Pathology · 46 citations

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

openalex 2023
Not yet classified

Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan D. Welch, Bahaa Elgendy, Lamees Hegazy et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2 citations

A Synthetic ERRα Agonist Induces an Acute Aerobic Exercise Response and Enhances Exercise Capacity

openalex 2022
Not yet classified

Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale · Research Journal of Science and Technology · 0 citations

Unlocking the potential: SLU-PP-332 and the future of exercise Enhancement and Metabolic health

openalex 2024
Systematic review

de Souza-Lima J, Astrosa-Martin BD, Galaz-Rodríguez CA, Silva-Bernal JE, Orellana-Pizarro LI, Mena-Díaz CA

[Pharmacological Activation of ERRα/β/γ as an Exercise Mimetic: Potential Therapeutic Applications].

pubmed 2026
Not yet classified

Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B

Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.

pubmed 2026
Not yet classified

Avliyakulov NK, Sobolevsky T, Ahrens E

Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes.

pubmed 2026
Not yet classified

Möller T, Krug O, Thevis M

In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential.

pubmed
Not yet classified

Billon C, Appourchaux K, Côté I, Burris TP

An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity.

pubmed 2026
Not yet classified

Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

pubmed 2026
Not yet classified

Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker...

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

pubmed
Not yet classified

Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

pubmed
Not yet classified

Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B · International journal of biological macromolecules

Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.

pmc 2026
Not yet classified

Möller T, Krug O, Thevis M · Rapid communications in mass spectrometry : RCM

In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential.

pmc
Not yet classified

Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U · Frontiers in physiology

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

pmc 2026
Not yet classified

Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP · The Journal of pharmacology and experimental therapeutics

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

pmc
Not yet classified

Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker...

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

pmc
Not yet classified

Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez...

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.

pmc 2023
Not yet classified

Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP · ACS chemical biology

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

pmc
Not yet classified

ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity. This capability prompted the consideration of these compounds...

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

crossref 2026

Connected data hub

Records with source provenance.

Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.

Open Access Article

7 records
pmcAutomated import

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U · Frontiers in physiology

PMC122772872026-09-27
pmcAutomated import

Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.

Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B · International journal of biological macromolecules

PMC131126012026-04-01
pmcAutomated import

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.

Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK,...

PMC107342812023-12-01
pmcAutomated import

In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential.

Möller T, Krug O, Thevis M · Rapid communications in mass spectrometry : RCM

PMC1283557227 Sep 2026
pmcAutomated import

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP · The Journal of pharmacology and experimental therapeutics

PMC1080178727 Sep 2026
pmcAutomated import

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M,...

PMC1084259927 Sep 2026
pmcAutomated import

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP...

PMC1158417027 Sep 2026

Publication

8 records
pubmedAutomated import

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U

406926962026-09-27
pubmedAutomated import

Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.

Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B

418504492026-04-01
pubmedAutomated import

Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes.

Avliyakulov NK, Sobolevsky T, Ahrens E

416884152026-03-01
pubmedAutomated import

[Pharmacological Activation of ERRα/β/γ as an Exercise Mimetic: Potential Therapeutic Applications].

de Souza-Lima J, Astrosa-Martin BD, Galaz-Rodríguez CA, Silva-Bernal JE, Orellana-Pizarro LI, Mena-Díaz CA

420246942026-02-01
pubmedAutomated import

An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity.

Billon C, Appourchaux K, Côté I, Burris TP

414210472026-01-01
pubmedAutomated import

In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential.

Möller T, Krug O, Thevis M

4158868727 Sep 2026
pubmedAutomated import

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M,...

3796190327 Sep 2026
pubmedAutomated import

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP

3773980627 Sep 2026

Article

7 records
openalexAutomated import

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

Tristan Möller, Oliver Krug, Mario Thevis · Rapid Communications in Mass Spectrometry · 1 citations

10.1002/rcm.700392026-01-26
openalexAutomated import

Unlocking the potential: SLU-PP-332 and the future of exercise Enhancement and Metabolic health

Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale · Research Journal of Science and Technology · 0 citations

10.52711/2349-2988.2024.000472024-12-05
openalexAutomated import

Can SLU-PP-332 be a new drug to prevent COVID-19?

Bogdan-Alexandru HAGIU · Medical Hypotheses · 1 citations

10.1016/j.mehy.2024.1113622024-04-30
openalexAutomated import

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Scarpa Wilderman, Lei Qi, Andrea Graves et al. · Circulation · 67 citations

10.1161/circulationaha.123.0665422023-11-14
openalexAutomated import

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

Cyrielle Billon, Emmalie Schoepke, Amer Avdagic, Arindam Chatterjee, Andrew A. Butler, Bahaa Elgendy et al. · Journal of Pharmacology and Experimental Therapeutics · 30 citations

10.1124/jpet.123.0017332023-09-22
openalexAutomated import

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

Xiaoxin X. Wang, Komuraiah Myakala, Andrew E. Libby, Ewa Krawczyk, Julia Panov, Bryce A. Jones et al. · American Journal Of Pathology · 46 citations

10.1016/j.ajpath.2023.07.0082023-09-17
openalexAutomated import

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan D. Welch, Bahaa Elgendy, Lamees Hegazy et al. · ACS Chemical Biology · 43 citations

10.1021/acschembio.2c007202023-03-29

Scholarly Work

8 records
crossrefAutomated import

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity. This...

10.1002/rcm.700392026-01-26
crossrefAutomated import

Rödlistade arter i Sverige 2025

Rödlistade arter i Sverige 2025 redovisar risken för att enskilda arter av djur, växter, svampar och alger ska försvinna från Sverige. Den är framtagen enligt IUCN:s rödlistningskriterier. I rödlistan bedöms risken att enskilda arter av djur, växter, svampar...

10.54612/a.6scftkgu7u2026-01-01
crossrefAutomated import

Developments in proximal crop sensing for precision agriculture

This chapter presents an overview of proximal sensing techniques used in practical precision agriculture, with the overall aim of contributing to more sustainable crop production. To provide perspective on the usefulness of crop sensors, the chapter starts with...

10.19103/as.2025.0152.022025-11-11
crossrefAutomated import

SLU-PP-332 AND RELATED ERRα AGONISTS: A FOCUSED MINIREVIEW OF METABOLIC REGULATION, AND THERAPEUTIC POTENTIAL

The global burden of metabolic disorders, including obesity and type 2 diabetes, necessitates innovative therapeutic strategies. SLU-PP-332, a synthetic agonist of estrogen-related receptor α (ERRα), has emerged as a promising exercise mimetic, demonstrating preclinical efficacy in enhancing mitochondrial...

10.22270/ujpr.v10i3.13552025-07-15
crossrefAutomated import

Can SLU-PP-332 be a new drug to prevent COVID-19?

B.-A. Hagiu · Elsevier BV

10.1016/j.mehy.2024.1113622024-06-01
crossrefAutomated import

Abstract 9682: The Cardiac Protective Effects of Novel Synthetic Pan-Estrogen Related Receptor Agonists Slu-pp-332 and Slu-pp-915

Introduction: Estrogen receptor-related orphan receptors ERRα and ERRγ are essential regulators for cardiac metabolism. Mice lacking ERRα and ERRγ develops lethal cardiomyopathy and heart failure. Therefore, activation of ERR is a potential therapeutic intervention for HF treatment. However,...

10.1161/circ.144.suppl_1.96822021-11-16
crossrefAutomated import

Sustainable systems for integrated fish and vegetable production: new perspectives on aquaponics

B. W. Alsanius, S. Khalil, A. Tadesse, A. K. Rosberg, K. J. Bergstrand, R. Hartmann, L. Mogren, M. Alam, M. Grudén, T. Naznin, A. Getahun · Burleigh Dodds Science Publishing

10.19103/as.2019.0052.042019-09-10
crossrefAutomated import

SLU Journal of Science and Technology

· Sule Lamido University Kafin Hausa

10.56471/slujst27 Sep 2026

Preprint

1 records
openalexAutomated import

A Synthetic ERRα Agonist Induces an Acute Aerobic Exercise Response and Enhances Exercise Capacity

Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan D. Welch, Bahaa Elgendy, Lamees Hegazy et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2 citations

10.1101/2022.10.05.5109742022-10-07
Responsible use of information

Fitzbio provides educational and research reference material. It does not diagnose, prescribe or replace advice from a qualified healthcare professional.