Research context
A peptide mixture used in neurological research; regulatory status varies by country.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Neuroscience
Cerebrolysin
A peptide mixture used in neurological research; regulatory status varies by country.
73 connected records48 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Choi JM, Jo KW
An Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review.
pubmed
Ziąbska H, Kobayashi A, Karliński M
Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.
pubmed 2026
Eichel R, Teitcher M, Mausbach S, Poplavska A, Shqair S, Eichel R, David EB, Borodetsky V, Bornstein N
Post-endovascular thrombectomy perfusion imaging (CT and MR) as a prognostic biomarker and patient-selection tool for adjuvant therapy: A systematic review, meta-analysis, and clinical threshold framework.
pubmed 2026
Roje Bedeković M, Ivona J, Bosnar Puretić M
Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.
pubmed 2026
Romano M
Cerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report.
pubmed 2026
Chiu HC, Yangchen Y, Pengiran Tengah DSNA, Chum NN, Lin Y, Fong WC, Pamidimukkala V, Pandian JD, Tjandrawidjaja G, Uchiyama S, Oh MS, Keosodsay S, Tan KS, Ravdan A, Lay PP, Thapa L, Siddiqui M, Navarro JC, Chang HM, Ranawaka UK, Lee TH, Chan L,...
Research-Evidence-Practice Gaps in Post-stroke Neuro-recovery Pharmacological Therapies in Asia.
pubmed
Caba IC, Iorga M, Mihăianu IG, Agoroaei L, Jităreanu A, Iurcov ROC
Predictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
pubmed
Teng H, Li C, Wang M, Zhang J, Zhang Y, Chopp M, Zhang ZG
Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
pubmed
The goal of this interventional study is to Measure the potential benefits of combined administration of cerebrolysin and amantadine sulfate as an add-on therapy to the standard management of patients admitted to the ICU with traumatic brain injury.
Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU
clinicaltrials 2023
This clinical trial was performed to assess the clinical efficacy and safety of two 4 week treatment courses of daily intravenous administration of Cerebrolysin (20mL \[milliliter\] IV \[intravenous\] per day). The study was performed as prospective, randomised, double-blind, placebo-controlled, parallel group, multicentre study with 2...
A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia
clinicaltrials 2009
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU). Delirium is a serious complication that prolongs hospital stay and contributes to poor outcomes and increased risk of...
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
clinicaltrials 2023
Ischemic stroke (IS) causes high mortality and severe disability. To improve outcome it's very important to choose the right way of the management of the patient and an appropriate drugs. There is a large number of the so-called neuroprotective drugs, which were effective in laboratory,...
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.
clinicaltrials 2011
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke. Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury Intervention: 30 ml cerebrolysin + 70 ml normal saline, days 4-17, once/day, intravenously or 100 ml...
Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness
clinicaltrials 2020
Delirium is a severe problem in critically ill patients, and it is associated with increased morbidity, mortality, and extended stay in hospital. The pathophysiology of delirium is multifactorial and still poorly recognized. Several authors proposed different pathomechanisms of delirium. The most likely of these are...
Cerebrolysin in Critically Ill Patients With Delirium
clinicaltrials 2024
Stroke is a leading cause of adult long-term disability worldwide. Recovery of arm and hand function after stroke is limited to about 50% of patients and full recovery is achieved in only 12% of stroke survivors by 6 months after stroke. Within the first 8-12...
IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE
clinicaltrials 2019
The purpose of this trial is to investigate safety and efficacy of Cerebrolysin as add-on therapy to standard care in patients with acute traumatic brain injury (TBI). The study duration for each patient is 180 days.
The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery
clinicaltrials 2012
Choi J
Improvement of aphasia deficits following traumatic intracranial hemorrhage: a case report.
pubmed 2026
The SARS-CoV-2 pandemic has consisted of multiple surges of infection because of continuous viral mutations. The WHO and CDC have defined the main SARS-CoV-2 variants based on international and national data for the circulation of SARS-CoV-2 into at least 4 waves. Studies from different parts...
Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants
clinicaltrials 2024
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to donepezil in patients with mild to moderate dementia of Alzheimer's Type (DAT). In addition, a traditional approach will be taken based on the evaluation of the separate risk and benefit...
Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT)
clinicaltrials 2013
It should be shown that Cerebrolysin in combination with Alteplase, the medication that should recover the blood flow through the brain, is an effective and save medication to treat ischeamic stroke.
Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke
clinicaltrials 2009
The study investigated the clinical efficacy and safety of a 10-day course of therapy with daily intravenous administration of 30mL Cerebrolysin based on a comparison with Placebo in patients with acute ischemic stroke. 1070 patients were randomized in this trial in 2 parallel groups, one...
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
clinicaltrials 2009
The overall aim of the study is to assess the effect of Cerebrolysin on physical and mental development of preterm infants by Denver Scale II at different ages of 5, 7 and 12 months
Cerebrolysin and Neurodevelopment in Preterm Infants
clinicaltrials 2018
The standard therapy for acute ischemic posterior circulation stroke (PCS) often leads to poor functional outcomes and high mortality rates, despite all advances in reperfusion therapy. Recent trials have shown that adding Cerebrolysin, a cerebral neuroprotective agent, to standard therapy for patients with acute ischemic...
Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
clinicaltrials 2024
Down syndrome is a genetic disorder that causes delay in both physical growth and mental development. It is the most frequently reported chromosomal abnormality and the most common genetic syndrome. Down syndrome is caused by trisomy of all or part of the genetic material of...
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome
clinicaltrials 2021
Choi J · Journal of medicine and life
Improvement of aphasia deficits following traumatic intracranial hemorrhage: a case report.
pmc 2026
Ziąbska H, Kobayashi A, Karliński M · Case reports in neurological medicine
Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.
pmc 2026
Roje Bedeković M, Ivona J, Bosnar Puretić M · Journal of medicine and life
Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.
pmc 2026
Romano M · Journal of medicine and life
Cerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report.
pmc 2026
Caba IC, Iorga M, Mihăianu IG, Agoroaei L, Jităreanu A, Iurcov ROC · Healthcare (Basel, Switzerland)
Predictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
pmc
Athari SZ, Farajdokht F, Mohajeri D, Nourazar MA · Basic and clinical neuroscience
Synergistic Effects of Cerebrolysin and Aerobic Exercise on 6-hydroxydopamine-induced Model of Parkinson Disease in Adult Male Rats.
pmc
Akbari-Gharalari N, Aliyari-Serej Z, Ghahremani-Nasab M, Zangbar HS, Yahyavi Y, Nezhadshahmohammad F, Ebrahimi-Kalan A · The journal of spinal cord medicine
Cerebrolysin-loaded platelet-rich plasma exosomes: Restoring immune homeostasis via TNF-α/IL-10 modulation and apoptosis targeting for spinal cord injury repair.
pmc 2026
Teng H, Li C, Wang M, Zhang J, Zhang Y, Chopp M, Zhang ZG · Cells
Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
pmc
· Ovid Technologies (Wolters Kluwer Health)
Cerebrolysin for Acute Ischemic Stroke
crossref 2026
· Ovid Technologies (Wolters Kluwer Health)
The CARS Study: Encouraging Results for Stroke Recovery with Cerebrolysin
crossref 2016
· Springer New York
Silver Nanoparticles and Cerebrolysin Treatment
crossref 2013
Dafin Muresanu · Springer Science and Business Media LLC
Can Cerebrolysin improve recovery after traumatic brain injury?
crossref 2018
· Springer New York
Nanowired Cerebrolysin and Superior Neuroprotective Effects in Silver Neurotoxicity
crossref 2013
Alexey Shmonin · Morressier
COMBINATION OF CEREBROLYSIN AND OCCUPATIONAL THERAPY FOR MEN WITH POST-STROKE DEPRESSION
crossref 2018
Aamir Al Mosawi · BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
P413 The use of cerebrolysin in pervasive developmental disorders
crossref 2019
Dominika Berent, Krzysztof Zboralski, Marian Macander · Military Institute of Aviation Medicine
ANTIOXIDANT PROPERTIES OF CEREBROLYSIN – AN OLD DRUG WITH NEWLY DISCOVERED CAPABILITIES
crossref 2014
Dafin Fior Muresanu, Wolf‐Dieter Heiss, Volker Hoemberg, Ovidiu Alexandru Bajenaru, Cristian Dinu Popescu, Johannes Vester et al. · Stroke · 161 citations
Cerebrolysin and Recovery After Stroke (CARS)
openalex 2015
Chunling Zhang, Michael Chopp, Yisheng Cui, Lei Wang, Ruilan Zhang, Li Zhang et al. · Journal of Neuroscience Research · 198 citations
Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke
openalex 2010
Greg L. Plosker, Serge G. Gauthier · Drugs & Aging · 81 citations
Cerebrolysin
openalex 2009
Wolf‐Dieter Heiss, Michael Brainin, Natan M. Bornstein, J Tuomilehto, Zhen Yi Hong · Stroke · 130 citations
Cerebrolysin in Patients With Acute Ischemic Stroke in Asia
openalex 2012
Ning Chen, Mi Yang, Jian Guo, Muke Zhou, Cairong Zhu, Li He · Cochrane Database of Systematic Reviews · 91 citations
Cerebrolysin for vascular dementia
openalex 2013
Li Zhang, Michael Chopp, Dieter H. Meier, Stefan Winter, Lei Wang, Alexandra Szalad et al. · Stroke · 148 citations
Sonic Hedgehog Signaling Pathway Mediates Cerebrolysin-Improved Neurological Function After Stroke
openalex 2013
Lilia E Ziganshina, Tatyana Abakumova, Alexandra Kuchaeva · Cochrane Database of Systematic Reviews · 81 citations
Cerebrolysin for acute ischaemic stroke
openalex 2010
G Ladurner, Pavel Kalvach, Herbert Moessler · Journal of Neural Transmission · 118 citations
Neuroprotective treatment with Cerebrolysin in patients with acute stroke: a randomised controlled trial
openalex 2004
Connected data hub
Records with source provenance.
Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.
Clinical Trial
40 recordsclinicaltrialsAdmin reviewed
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology and Intensive Neurological Therapy, UMC Ljubljana.
clinicaltrialsAdmin reviewed
Safety and Feasibility of Using Cerebrolysin in the Treatment of Primary Intracerebral Hemorrhage - a Prospective Randomized Open Blinded End-point Trial
This study is designed to determine the safety and feasibility of using Cerebrolysin in treating primary intracerebral hemorrhage (ICH). This is a multicenter, prospective, randomized, open-label, blinded end-point, phase IV parallel group study done in specialized stroke treatment...
clinicaltrialsAdmin reviewed
Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study
" This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment. The patients are divided into two groups: the experimental group, which receives a combination...
clinicaltrialsAdmin reviewed
Cerebrolysin in Critically Ill Patients With Delirium
Delirium is a severe problem in critically ill patients, and it is associated with increased morbidity, mortality, and extended stay in hospital. The pathophysiology of delirium is multifactorial and still poorly recognized. Several authors proposed different pathomechanisms of...
clinicaltrialsAdmin reviewed
Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
The standard therapy for acute ischemic posterior circulation stroke (PCS) often leads to poor functional outcomes and high mortality rates, despite all advances in reperfusion therapy. Recent trials have shown that adding Cerebrolysin, a cerebral neuroprotective agent, to...
clinicaltrialsAdmin reviewed
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy
Acute ischemic stroke caused by blockage of a large brain artery can lead to severe disability. Endovascular thrombectomy is a catheter-based procedure used to remove the blood clot and restore blood flow. It can benefit selected patients treated...
clinicaltrialsAdmin reviewed
Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke
A prospective, single-center study would be carried out in the Neurology Department of the University Hospital "Dr. José Eleuterio González" in order to analyze the effect of cerebrolysin on the blood-brain-barrier in patients with ischemic stroke with personal...
clinicaltrialsAdmin reviewed
Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants
The SARS-CoV-2 pandemic has consisted of multiple surges of infection because of continuous viral mutations. The WHO and CDC have defined the main SARS-CoV-2 variants based on international and national data for the circulation of SARS-CoV-2 into at...
clinicaltrialsAdmin reviewed
CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke
The study investigates whether Cerebrolysin stabilizes blood-brain barrier integrity in a manner that can be monitored using serum levels of the principal tight junction proteins, e.g., occludin (OCL), claudin-5 (CLN), and zonula occludens-1 (ZO-1), or other molecules known...
clinicaltrialsAdmin reviewed
Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU
The goal of this interventional study is to Measure the potential benefits of combined administration of cerebrolysin and amantadine sulfate as an add-on therapy to the standard management of patients admitted to the ICU with traumatic brain injury.
clinicaltrialsAdmin reviewed
A Prospective, Trial About Safety and Efficacy of Combined Treatment With Cerebrolysin in Acute Ischemic Hemispheric Stroke Patients Undergoing EndoVascular Treatment (EVT)
The goal of this clinical trial is investigate the efficacy of a neuro/vascular-protective treatment with the drug Cerebrolysin in patients with acute ischemic stroke. starting immediately after completion of a EVT therapy. The main question the study aims...
clinicaltrialsAdmin reviewed
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy
Bell's palsy, a peripheral facial nerve paresis, is the most common disorder of the facial nerve and one of the most common mononeuropathies. Many patients with Bell's palsy will develop some complications such as synkinesis, crocodile tears and...
clinicaltrialsAdmin reviewed
Evaluation of the Effect of Neuroprotective Drug on Treatment Result in Patients After Traumatic Brain Injury
Traumatic Brain Injury TBI is one of the most common causes of death and recovery failure worldwide. Each element of treatment, starting from possible surgical treatment, patient monitoring and neuroprotective treatment, can be important in the overall outcome...
clinicaltrialsAdmin reviewed
CERebrolysin In CADASIL
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL. In addition, a traditional approach will be taken based on an evaluation of the separate risk...
clinicaltrialsAdmin reviewed
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU). Delirium is a serious complication that prolongs hospital stay and contributes...
clinicaltrialsAdmin reviewed
Hair Repigmentation During Cerebrolysin Therapy
Open-label histological study of scalp biopsies from patients undergoing treatment with Cerebrolysin as therapy for cerebrovascular disease. The aim is to assess by histological techniques the causes of follicular repigmentation that occurs during the Cerebrolysin treatment.
clinicaltrialsAdmin reviewed
Early Administration of Cerebrolysin on the Outcome of Patients With Acute Stroke Undergoing EVT
Background: Stroke is the third major cause of death and disability worldwide. It was shown that combining early reperfusion therapy (thrombolysis and/or thrombectomy) with stroke unit care and immediate rehabilitation have beneficial effects on the patient recovery and...
clinicaltrialsAdmin reviewed
Effects of Cerebrolysin on Level of Consciousness and Brain Metabolism in Disorder of Consciousness After Stroke: Single Center Randomized Controlled Study
The purpose of this study was to determine the effect of stroke on post-stroke level of consciousness through a double-blind, placebo-controlled, randomized study design. And Brain 18F-FDG PET was used to reveal the mechanism of recovery after cerebrolysin...
clinicaltrialsAdmin reviewed
Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke.
This study is designed to determine the efficacy and safety of Cerebrolysin treatment as an add- on therapy to mechanical thrombectomy (MT) in reducing global disability in subjects with acute ischemic stroke (AIS). The investigators have planned a...
clinicaltrialsAdmin reviewed
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome
Down syndrome is a genetic disorder that causes delay in both physical growth and mental development. It is the most frequently reported chromosomal abnormality and the most common genetic syndrome. Down syndrome is caused by trisomy of all...
clinicaltrialsAdmin reviewed
Cerebrolycin for Treatment of Covid-related Anosmia and Ageusia
The loss of smell and taste is a prominent symptom of COVID-19. Studies found that patterns of smell loss due to Covid-19 infection differ from that of other respiratory viruses being much more profound in the Covid-19 patents...
clinicaltrialsAdmin reviewed
Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke. Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury Intervention: 30 ml cerebrolysin + 70 ml normal saline,...
clinicaltrialsAdmin reviewed
IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE
Stroke is a leading cause of adult long-term disability worldwide. Recovery of arm and hand function after stroke is limited to about 50% of patients and full recovery is achieved in only 12% of stroke survivors by 6...
clinicaltrialsAdmin reviewed
Cerebrolysin and Neurodevelopment in Preterm Infants
The overall aim of the study is to assess the effect of Cerebrolysin on physical and mental development of preterm infants by Denver Scale II at different ages of 5, 7 and 12 months
clinicaltrialsAdmin reviewed
Cerebrolysin REGistry Study in Stroke - a High-quality Observational Study of Comparative Effectiveness
This study investigates the clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with moderate to severe neurological deficits after acute ischemic stroke.
clinicaltrialsAdmin reviewed
Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke
This study, E-COMPASSII is a phase IV clinical trial designed as a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. This study will enroll 80 subacute stroke patients with severe motor involvement. Primary objective is to demonstrate the efficacy of...
clinicaltrialsAdmin reviewed
Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm
The aim of the present clinical phase IV study is to estimate the influence of Cerebrolysin in combination with standard therapy on the dynamics of recovery of the paretic upper limb in patients with acute ischemic stroke. Each...
clinicaltrialsAdmin reviewed
Cerebrolysin REGistry Study in Stroke
Investigation of clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with acute ischemic stroke.
clinicaltrialsAdmin reviewed
Dl-3-n-butylphthalide and Cerebrolysin Treatment in Acute Ischemic Stroke
The investigators conducted a randomized, double-blind, trial enrolled 60 patients within 12 hours of acute ischemic stroke (AIS) in China. Patients were randomly assigned to receive a 10-day infusion of dl-3-n-butylphthalide (NBP) or cerebrolysin, or placebo. National Institutes...
clinicaltrialsAdmin reviewed
Cerebrolysin Neural Repair Therapy in Children With Traumatic Brain Injury and Cerebral Palsy
Cerebral palsy (CP) is the most frequent cause of motor handicap among children. The economic burden of CP in USA includes $1.18 billion in direct medical costs, $1.05 billion in direct non-medical costs, and an additional $9.24 billion...
clinicaltrialsAdmin reviewed
Effects of Cerebrolysin on Motor Recovery in Patients With Subacute Stroke
This study, E-COMPASS is a phase IV clinical trial designed as a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. This study will enroll 75 subacute stroke patients with unilateral motor dysfunction. Primary objective is to demonstrate the efficacy of...
clinicaltrialsAdmin reviewed
Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT)
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to donepezil in patients with mild to moderate dementia of Alzheimer's Type (DAT). In addition, a traditional approach will be taken based on the...
clinicaltrialsAdmin reviewed
Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage
This is a randomized, placebo-controlled, single-center clinical trial investigating the effectiveness of administrating intravenous Cerebrolysin™ (EVER NEURO Pharma, Austria), a preparation of low-molecular weight neurotrophic peptides and free amino acids, in improving the functional outcome of patients suffering...
clinicaltrialsAdmin reviewed
The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery
The purpose of this trial is to investigate safety and efficacy of Cerebrolysin as add-on therapy to standard care in patients with acute traumatic brain injury (TBI). The study duration for each patient is 180 days.
clinicaltrialsAdmin reviewed
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.
Ischemic stroke (IS) causes high mortality and severe disability. To improve outcome it's very important to choose the right way of the management of the patient and an appropriate drugs. There is a large number of the so-called...
clinicaltrialsAdmin reviewed
Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy
The purpose of this study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy after hospital discharge.
clinicaltrialsAdmin reviewed
A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia
This clinical trial was performed to assess the clinical efficacy and safety of two 4 week treatment courses of daily intravenous administration of Cerebrolysin (20mL \[milliliter\] IV \[intravenous\] per day). The study was performed as prospective, randomised, double-blind,...
clinicaltrialsAdmin reviewed
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease
The study was performed to compare the safety and efficacy of Cerebrolysin (10 mililiters \[ml\]), Aricept (10 miligrams \[mg\]), and a combination of both treatments on cognitive performance and global function in patients with probable Alzheimer's Disease (AD)....
clinicaltrialsAdmin reviewed
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
The study investigated the clinical efficacy and safety of a 10-day course of therapy with daily intravenous administration of 30mL Cerebrolysin based on a comparison with Placebo in patients with acute ischemic stroke. 1070 patients were randomized in...
clinicaltrialsAdmin reviewed
Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke
It should be shown that Cerebrolysin in combination with Alteplase, the medication that should recover the blood flow through the brain, is an effective and save medication to treat ischeamic stroke.
Publication
9 recordspubmedAutomated import
Post-endovascular thrombectomy perfusion imaging (CT and MR) as a prognostic biomarker and patient-selection tool for adjuvant therapy: A systematic review, meta-analysis, and clinical threshold framework.
Eichel R, Teitcher M, Mausbach S, Poplavska A, Shqair S, Eichel R, David EB, Borodetsky V, Bornstein N
pubmedAutomated import
Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.
Ziąbska H, Kobayashi A, Karliński M
pubmedAutomated import
Improvement of aphasia deficits following traumatic intracranial hemorrhage: a case report.
Choi J
pubmedAutomated import
Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.
Roje Bedeković M, Ivona J, Bosnar Puretić M
pubmedAutomated import
Cerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report.
Romano M
pubmedAutomated import
An Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review.
Choi JM, Jo KW
pubmedAutomated import
Research-Evidence-Practice Gaps in Post-stroke Neuro-recovery Pharmacological Therapies in Asia.
Chiu HC, Yangchen Y, Pengiran Tengah DSNA, Chum NN, Lin Y, Fong WC, Pamidimukkala V, Pandian JD, Tjandrawidjaja G, Uchiyama S, Oh MS, Keosodsay S, Tan KS, Ravdan A, Lay PP, Thapa L, Siddiqui M, Navarro JC, Chang...
pubmedAutomated import
Predictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
Caba IC, Iorga M, Mihăianu IG, Agoroaei L, Jităreanu A, Iurcov ROC
pubmedAutomated import
Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
Teng H, Li C, Wang M, Zhang J, Zhang Y, Chopp M, Zhang ZG
Open Access Article
8 recordspmcAutomated import
Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.
Ziąbska H, Kobayashi A, Karliński M · Case reports in neurological medicine
pmcAutomated import
Improvement of aphasia deficits following traumatic intracranial hemorrhage: a case report.
Choi J · Journal of medicine and life
pmcAutomated import
Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.
Roje Bedeković M, Ivona J, Bosnar Puretić M · Journal of medicine and life
pmcAutomated import
Cerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report.
Romano M · Journal of medicine and life
pmcAutomated import
Cerebrolysin-loaded platelet-rich plasma exosomes: Restoring immune homeostasis via TNF-α/IL-10 modulation and apoptosis targeting for spinal cord injury repair.
Akbari-Gharalari N, Aliyari-Serej Z, Ghahremani-Nasab M, Zangbar HS, Yahyavi Y, Nezhadshahmohammad F, Ebrahimi-Kalan A · The journal of spinal cord medicine
pmcAutomated import
Predictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
Caba IC, Iorga M, Mihăianu IG, Agoroaei L, Jităreanu A, Iurcov ROC · Healthcare (Basel, Switzerland)
pmcAutomated import
Synergistic Effects of Cerebrolysin and Aerobic Exercise on 6-hydroxydopamine-induced Model of Parkinson Disease in Adult Male Rats.
Athari SZ, Farajdokht F, Mohajeri D, Nourazar MA · Basic and clinical neuroscience
pmcAutomated import
Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
Teng H, Li C, Wang M, Zhang J, Zhang Y, Chopp M, Zhang ZG · Cells
Scholarly Work
8 recordscrossrefAutomated import
Cerebrolysin for Acute Ischemic Stroke
· Ovid Technologies (Wolters Kluwer Health)
crossrefAutomated import
P413 The use of cerebrolysin in pervasive developmental disorders
Aamir Al Mosawi · BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
crossrefAutomated import
Can Cerebrolysin improve recovery after traumatic brain injury?
Dafin Muresanu · Springer Science and Business Media LLC
crossrefAutomated import
COMBINATION OF CEREBROLYSIN AND OCCUPATIONAL THERAPY FOR MEN WITH POST-STROKE DEPRESSION
Alexey Shmonin · Morressier
crossrefAutomated import
The CARS Study: Encouraging Results for Stroke Recovery with Cerebrolysin
· Ovid Technologies (Wolters Kluwer Health)
crossrefAutomated import
ANTIOXIDANT PROPERTIES OF CEREBROLYSIN – AN OLD DRUG WITH NEWLY DISCOVERED CAPABILITIES
Dominika Berent, Krzysztof Zboralski, Marian Macander · Military Institute of Aviation Medicine
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Silver Nanoparticles and Cerebrolysin Treatment
· Springer New York
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Nanowired Cerebrolysin and Superior Neuroprotective Effects in Silver Neurotoxicity
· Springer New York
Article
7 recordsopenalexAutomated import
Cerebrolysin and Recovery After Stroke (CARS)
Dafin Fior Muresanu, Wolf‐Dieter Heiss, Volker Hoemberg, Ovidiu Alexandru Bajenaru, Cristian Dinu Popescu, Johannes Vester et al. · Stroke · 161 citations
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Sonic Hedgehog Signaling Pathway Mediates Cerebrolysin-Improved Neurological Function After Stroke
Li Zhang, Michael Chopp, Dieter H. Meier, Stefan Winter, Lei Wang, Alexandra Szalad et al. · Stroke · 148 citations
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Cerebrolysin for vascular dementia
Ning Chen, Mi Yang, Jian Guo, Muke Zhou, Cairong Zhu, Li He · Cochrane Database of Systematic Reviews · 91 citations
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Cerebrolysin in Patients With Acute Ischemic Stroke in Asia
Wolf‐Dieter Heiss, Michael Brainin, Natan M. Bornstein, J Tuomilehto, Zhen Yi Hong · Stroke · 130 citations
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Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke
Chunling Zhang, Michael Chopp, Yisheng Cui, Lei Wang, Ruilan Zhang, Li Zhang et al. · Journal of Neuroscience Research · 198 citations
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Cerebrolysin
Greg L. Plosker, Serge G. Gauthier · Drugs & Aging · 81 citations
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Neuroprotective treatment with Cerebrolysin in patients with acute stroke: a randomised controlled trial
G Ladurner, Pavel Kalvach, Herbert Moessler · Journal of Neural Transmission · 118 citations
Reference-entry
1 recordsopenalexAutomated import
Cerebrolysin for acute ischaemic stroke
Lilia E Ziganshina, Tatyana Abakumova, Alexandra Kuchaeva · Cochrane Database of Systematic Reviews · 81 citations
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[Expert Council resolution: adjunctive pharmacotherapy for hyperkinetic disorders (attention deficit hyperactivity disorder) in children and adolescents].PMID 42910684 · 2026Adjunctive Cerebrolysin therapy following mechanical thrombectomy for tandem right internal carotid artery and middle cerebral artery occlusion with residual post-procedural perfusion deficit: a case report.PMID 42891269 · 2026 AugImprovement of aphasia deficits following traumatic intracranial hemorrhage: a case report.PMID 42751610 · 2026 JulAn Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review.PMID 42675994 · 2026 Sep 1Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.PMID 42666484 · 2026Registered clinical studies
Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in StrokeNCT02768571 · COMPLETEDCerebrolysin and Neurodevelopment in Preterm InfantsNCT03506841 · COMPLETEDEvaluation of the Effect of Neuroprotective Drug on Treatment Result in Patients After Traumatic Brain InjuryNCT05807503 · COMPLETEDReviewed UniProt records
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