Research context
A synthetic growth-hormone secretagogue used in laboratory endocrine research.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Growth-hormone research
GHRP-6
A synthetic growth-hormone secretagogue used in laboratory endocrine research.
34 connected records34 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Wang L, Rodriguez-Ulloa A, Berlanga-Acosta J, García-Ojalvo A, Abreu-Cruz A, Gonzalez-López LJ, Besada-López V, Ramos-Gómez Y, Guillén-Nieto G, Jiang B · Pharmaceuticals (Basel, Switzerland)
Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.
pmc
Rahmania A, Zendehdel M, Hassanpour S · Poultry science
Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.
pmc 2026
Zhao X, Pan K, Li R, Liu M, Li D, Jia P, Han Z, Han ZC, Guo Z, Li Z, Li Q · Journal of nanobiotechnology
Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.
pmc
Ma L, Qu Q · Alzheimer's & Dementia
Chronic ghrelin administration suppresses IKK/NF‐κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ‐diabetic rats.
pmc 2025
Goudsward HJ, Ruiz-Velasco V, Stella SL , Jr, Herold PB, Holmes GM · Molecular pharmacology
Ghrelin Modulates Voltage-Gated Ca(2+) Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons.
pmc
Vera M. POPOVIC, Svetozar S Damjanovic, Dragan Micić, Marina Nikolic Djurovic, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 190 citations
Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.
openalex 1995
Inge Depoortere, Benedicte Y. De Winter, Theo Thijs, Joris De Man, Paul A. Pelckmans, Theo Louis Peeters · European Journal of Pharmacology · 142 citations
Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
openalex 2005
A Peñalva, Manuel Pombo, A. Carballo, J Barreiro, Felipe F. Casanueva, Carlos Diéguez · Clinical Endocrinology · 85 citations
Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP‐6
openalex 1993
Ángel Galindo García, Clara V. Álvarez, Roy G. Smith, Carlos Diéguez · Molecular Endocrinology · 93 citations
Regulation of PIT-1 Expression By Ghrelin and GHRP-6 Through the GH Secretagogue Receptor
openalex 2001
Fernando Cordido, A Peñalva, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 147 citations
Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity.
openalex 1993
Manuel Pombo, J Barreiro, A Peñalva, Roberto Peino, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 69 citations
Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6), or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection.
openalex 1995
Vera M. POPOVIC · The Journal of Clinical Endocrinology & Metabolism · 81 citations
Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level
openalex 1995
Keith M. Fairhall, Anita Mynett, I. C. A. F. Robinson · Journal of Endocrinology · 89 citations
Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action
openalex 1995
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
pubmed 2026
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M · Frontiers in endocrinology
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
pmc 2026
W. C. Huhn · The Endocrine Society
Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
crossref 1993
Cyril Y. Bowers · Springer US
GHRP-GH Secretagogues
crossref 1999
Growth hormone releasing peptides (GHRPs) stimulate secretion of endogenous growth hormone and are listed on the World Anti‐Doping Agency (WADA) Prohibited List. To develop an effective method for GHRPs anti‐doping control we have investigated metabolites of GHRP‐1, GHRP‐2, GHRP‐6, Hexarelin, and Ipamorelin in urine after...
Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP‐1, GHRP‐2, GHRP‐6, Hexarelin, and Ipamorelin
crossref 2015
Holly D. Cox, Cole M. Hughes, Daniel Eichner · Wiley
Detection of GHRP‐2 and GHRP‐6 in urine samples from athletes
crossref 2015
C. Y. Bowers · Humana Press
GHRP Historical Perspective: Basic and Clinical
crossref
Fibrosis is defined as the pathological accumulation of extracellular matrix proteins (ECMs) during the tissue repair response to an injury, which interferes with the functioning of the damaged organ or tissue, which is the underlying cause of multiple disorders that lead to high morbidity and...
Avances en Biotecnología: péptido liberador de hormonas de crecimiento 6 (GHRP-6)
crossref 2021
Svetozar Damjanović, Vera Popović, Milan Petakov, Marina Djurović, Carlos Dieguez, Felipe F. Casanueva · Walter de Gruyter GmbH
Pituitary Enlargement Due to Primary Hypothyroidism: Growth Hormone Response to GHRH, GHRP-6 and GHRH Plus GHRP-6
crossref 1996
Chen Chen, Iain J. Clarke · Elsevier
Intracellular GHRP Signalling
crossref 1999
Perez SL, Martinez L, Rosselli M, Nair RR
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
pubmed 2026
Ramírez ND, Schulman Fernández M, Torres PJ, Luque EM, Martínez MS, Cantarelli V, Castrogiovanni D, Ponzio MF, Carlini VP, Beltramone F, Perelló M, Motrich RD, Martini AC
Ghrelin impairs embryo development after ovarian hyperstimulation.
pubmed
Zhang L, Yuan J, Hu N, Yu J, Zhang L, Chen R, Wang X
The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.
pubmed
Wang L, Rodriguez-Ulloa A, Berlanga-Acosta J, García-Ojalvo A, Abreu-Cruz A, Gonzalez-López LJ, Besada-López V, Ramos-Gómez Y, Guillén-Nieto G, Jiang B
Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.
pubmed
Wang L, Berlanga-Acosta J, Yu H, García-Ojalvo A, Jiang T, Li N, Zhang Z, Guillén-Nieto G, Jiang B
Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis.
pubmed
Kihara M, Yamagiwa T, Katayama H, Kaiya H
Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption.
pubmed 2026
Rahmania A, Zendehdel M, Hassanpour S
Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.
pubmed 2026
Chen G, Dilixiati B, Zhou T, Rao X, Aimidoula R, Zhang W, Zhao H, Wusiman A, Zhu J
Ghrelin Receptor Blockade Restricts Hepatic Echinococcus granulosus Infection by Suppressing Host Cell Proliferation and Enhancing Fibrotic Encapsulation.
pubmed
Feng W, Fu X, Hu N, Chen R, Zhang L, Wang X
Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.
pubmed
Perez SL, Martinez L, Rosselli M, Nair RR · Frontiers in surgery
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
pmc 2026
Zhang L, Yuan J, Hu N, Yu J, Zhang L, Chen R, Wang X · Biomolecules
The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.
pmc
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Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.
Open Access Article
8 recordspmcAutomated import
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
Perez SL, Martinez L, Rosselli M, Nair RR · Frontiers in surgery
pmcAutomated import
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M · Frontiers in endocrinology
pmcAutomated import
Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.
Rahmania A, Zendehdel M, Hassanpour S · Poultry science
pmcAutomated import
Chronic ghrelin administration suppresses IKK/NF‐κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ‐diabetic rats.
Ma L, Qu Q · Alzheimer's & Dementia
pmcAutomated import
The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.
Zhang L, Yuan J, Hu N, Yu J, Zhang L, Chen R, Wang X · Biomolecules
pmcAutomated import
Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.
Wang L, Rodriguez-Ulloa A, Berlanga-Acosta J, García-Ojalvo A, Abreu-Cruz A, Gonzalez-López LJ, Besada-López V, Ramos-Gómez Y, Guillén-Nieto G, Jiang B · Pharmaceuticals (Basel, Switzerland)
pmcAutomated import
Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.
Zhao X, Pan K, Li R, Liu M, Li D, Jia P, Han Z, Han ZC, Guo Z, Li Z, Li Q · Journal of nanobiotechnology
pmcAutomated import
Ghrelin Modulates Voltage-Gated Ca(2+) Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons.
Goudsward HJ, Ruiz-Velasco V, Stella SL , Jr, Herold PB, Holmes GM · Molecular pharmacology
Publication
10 recordspubmedAutomated import
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
Perez SL, Martinez L, Rosselli M, Nair RR
pubmedAutomated import
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M
pubmedAutomated import
Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.
Rahmania A, Zendehdel M, Hassanpour S
pubmedAutomated import
Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption.
Kihara M, Yamagiwa T, Katayama H, Kaiya H
pubmedAutomated import
Ghrelin Receptor Blockade Restricts Hepatic Echinococcus granulosus Infection by Suppressing Host Cell Proliferation and Enhancing Fibrotic Encapsulation.
Chen G, Dilixiati B, Zhou T, Rao X, Aimidoula R, Zhang W, Zhao H, Wusiman A, Zhu J
pubmedAutomated import
Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.
Feng W, Fu X, Hu N, Chen R, Zhang L, Wang X
pubmedAutomated import
Ghrelin impairs embryo development after ovarian hyperstimulation.
Ramírez ND, Schulman Fernández M, Torres PJ, Luque EM, Martínez MS, Cantarelli V, Castrogiovanni D, Ponzio MF, Carlini VP, Beltramone F, Perelló M, Motrich RD, Martini AC
pubmedAutomated import
The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.
Zhang L, Yuan J, Hu N, Yu J, Zhang L, Chen R, Wang X
pubmedAutomated import
Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.
Wang L, Rodriguez-Ulloa A, Berlanga-Acosta J, García-Ojalvo A, Abreu-Cruz A, Gonzalez-López LJ, Besada-López V, Ramos-Gómez Y, Guillén-Nieto G, Jiang B
pubmedAutomated import
Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis.
Wang L, Berlanga-Acosta J, Yu H, García-Ojalvo A, Jiang T, Li N, Zhang Z, Guillén-Nieto G, Jiang B
Scholarly Work
8 recordscrossrefAutomated import
Avances en Biotecnología: péptido liberador de hormonas de crecimiento 6 (GHRP-6)
Fibrosis is defined as the pathological accumulation of extracellular matrix proteins (ECMs) during the tissue repair response to an injury, which interferes with the functioning of the damaged organ or tissue, which is the underlying cause of multiple...
crossrefAutomated import
Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP‐1, GHRP‐2, GHRP‐6, Hexarelin, and Ipamorelin
Growth hormone releasing peptides (GHRPs) stimulate secretion of endogenous growth hormone and are listed on the World Anti‐Doping Agency (WADA) Prohibited List. To develop an effective method for GHRPs anti‐doping control we have investigated metabolites of GHRP‐1, GHRP‐2,...
crossrefAutomated import
Detection of GHRP‐2 and GHRP‐6 in urine samples from athletes
Holly D. Cox, Cole M. Hughes, Daniel Eichner · Wiley
crossrefAutomated import
GHRP-GH Secretagogues
Cyril Y. Bowers · Springer US
crossrefAutomated import
Intracellular GHRP Signalling
Chen Chen, Iain J. Clarke · Elsevier
crossrefAutomated import
Pituitary Enlargement Due to Primary Hypothyroidism: Growth Hormone Response to GHRH, GHRP-6 and GHRH Plus GHRP-6
Svetozar Damjanović, Vera Popović, Milan Petakov, Marina Djurović, Carlos Dieguez, Felipe F. Casanueva · Walter de Gruyter GmbH
crossrefAutomated import
Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
W. C. Huhn · The Endocrine Society
crossrefAutomated import
GHRP Historical Perspective: Basic and Clinical
C. Y. Bowers · Humana Press
Article
8 recordsopenalexAutomated import
Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
Inge Depoortere, Benedicte Y. De Winter, Theo Thijs, Joris De Man, Paul A. Pelckmans, Theo Louis Peeters · European Journal of Pharmacology · 142 citations
openalexAutomated import
Regulation of PIT-1 Expression By Ghrelin and GHRP-6 Through the GH Secretagogue Receptor
Ángel Galindo García, Clara V. Álvarez, Roy G. Smith, Carlos Diéguez · Molecular Endocrinology · 93 citations
openalexAutomated import
Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6), or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection.
Manuel Pombo, J Barreiro, A Peñalva, Roberto Peino, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 69 citations
openalexAutomated import
Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.
Vera M. POPOVIC, Svetozar S Damjanovic, Dragan Micić, Marina Nikolic Djurovic, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 190 citations
openalexAutomated import
Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level
Vera M. POPOVIC · The Journal of Clinical Endocrinology & Metabolism · 81 citations
openalexAutomated import
Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action
Keith M. Fairhall, Anita Mynett, I. C. A. F. Robinson · Journal of Endocrinology · 89 citations
openalexAutomated import
Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity.
Fernando Cordido, A Peñalva, Carlos Diéguez, Felipe F. Casanueva · The Journal of Clinical Endocrinology & Metabolism · 147 citations
openalexAutomated import
Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP‐6
A Peñalva, Manuel Pombo, A. Carballo, J Barreiro, Felipe F. Casanueva, Carlos Diéguez · Clinical Endocrinology · 85 citations
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Latest research signals
Live results from PubMed, ClinicalTrials.gov and UniProt. These may not yet have been reviewed or stored in the Data Hub.
Recent PubMed records
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.PMID 42862021 · 2026 Sep 30Ghrelin Receptor Blockade Restricts Hepatic Echinococcus granulosus Infection by Suppressing Host Cell Proliferation and Enhancing Fibrotic Encapsulation.PMID 42799941 · 2026 Sep 26Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.PMID 42753464 · 2026 Sep 10Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.PMID 42465868 · 2026Ghrelin impairs embryo development after ovarian hyperstimulation.PMID 42461148 · 2026 Jul 1Registered clinical studies
Reviewed UniProt records
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