Research context
A cellular tripeptide central to redox biology and oxidative-stress research.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Antioxidant research
Glutathione
A cellular tripeptide central to redox biology and oxidative-stress research.
79 connected records57 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Hu Y, Wang J, Wang J, Deng Y, Chen W, Zhang Q
Resveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling.
pubmed
Liu F, Luo J, Feng L, Xia Y, Chen X, Xu Y, Liu Y
The association between neonatal respiratory distress syndrome and gut microbiota dysbiosis: evidence from metagenomics.
pubmed 2026
Sahin Z, Darwich NA, Duran T, Avci D, Silva LR, Sonmez F, Khalil MI
Green Synthesis of Silver Nanoparticles From Various Leaves Extract: Antioxidant, Anti-Inflammatory, Antibacterial Activities and Inhibitory Effect on Glutathione S-Transferase.
pubmed 2026
Rezazadeh F, Fassihi N, Mahdavi D, Maroufi S, Khorami ET, Tabesh A, Sedarat H
Salivary Level of Glutathione Reductase, Catalase, and Free Thiol in Patients With Temporomandibular Joint Disorder: A Cross-Sectional Study.
pubmed 2026
Xu R, Ning L, Zhao L, Lu Z, Zhang H, Xu W, Jia F
A Covalent Brush-on-Brush Polymer Programs Ordered Intracellular Activation of a Mitochondria-Disrupting Peptide.
pubmed
Yang Y, Shan G, Li H, Hou J, Wu H, Liu Q, He Y, Zhao S, Ge C, Zhou B, Zhang J, Sun Y, Yang Y
Metformin exhibits a synergistic effect with pyrotinib by inducing ferroptosis in HER2-positive cancers through the Keap1/Nrf2 pathway.
pubmed
Nakamura T, Inoki A, Das NK, Chen B, Khan A, Liu Y, Uygur B, Yen FS, Unlu G, Shah YM, Birsoy K
Cysteine excess triggers a mitochondrial iron-dependent cell death.
pubmed
Huang L, Wang H, Liu Y, Wang S, Teng S, Zhang X, Jiang Y, Bahitwa R, Zhao J, Wang Z
A rhamnogalacturonan I-enriched pectic polysaccharide from alfalfa and its protective effects against oxidative stress in Caenorhabditis elegans.
pubmed
Atopic dermatitis (AD), or atopic eczema, is a chronic relapsing, inflammatory skin disease, characterized by intense pruritus that leads to considerable burden on patients' quality of life (Sidbury et al., 2023). The dramatic rise of AD prevalence in the past half century is well documented,...
Comparison Between Topical N-acetyl Cysteine (NAC) in Cold Cream Versus Cold Cream in Mild and Moderate Atopic Dermatitis: Clinical and Bacteriological Evaluation. A Randomized Control Trial.
clinicaltrials 2025
This preclinical translational study aims to evaluate a new method of delivering lithium using gold nanoparticles for the treatment of bipolar disorder. Lithium is an effective treatment for bipolar disorder, but its clinical use is limited by a narrow therapeutic range and the risk of...
Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory Models
clinicaltrials 2026
The objective of this trial is to evaluate the effects of setria performance blend supplementation on endurance performance in healthy men.
Setria Performance Blend Supplementation
clinicaltrials 2019
Autism spectrum disorder (ASD) is a lifelong developmental disability that includes deficits in social communication and social interaction and restricted, repetitive patterns of behavior, interests, or activities. The current treatment approaches for the management of autism are expensive, showing unwanted adverse effects; alter the genetic...
Dates as a Functional Food for Autism
clinicaltrials 2020
The goal of the GlycOxiTOD observational registry is to improve the early detection and characterization of vascular and other target-organ damage in adults at increased cardiovascular risk. Target-organ damage (TOD) means changes in the arteries, heart, kidneys, or other organs that may develop before cardiovascular...
GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry
clinicaltrials 2024
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM). However, its non-glycemic effects are still largely unknown. The investigators will evaluate for the first time...
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
clinicaltrials 2017
The study will be conducted as a community-based, randomized, placebo-controlled, trial with four study groups. The overall objective of the study is to determine the optimal method for delivering zinc to young children, both for the prevention of zinc deficiency and treatment of diarrhea. In...
Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation
clinicaltrials 2015
The purpose of this study is to assess the efficacy of N-acetylcysteine (NAC) in preventing those with mild or moderate COVID-19 from progressing to severe disease
Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease
clinicaltrials 2020
Liang G, Zhu C, Sun H, Ji Y, Jiang H
Advances in Drug Delivery Systems for Breast Cancer: From Microenvironment Barriers and Smart Carriers to Clinical Translation Strategies.
pubmed 2026
Wang Y, Cai J, Kong X, Li J, Ge Y, Zhang Y, Chen Y, Zhu M, Gong H, Zhao D, Pi J
Promising Roles of Selenium Nanoparticles in Anti-Tuberculosis Therapy: Opportunities and Challenges.
pubmed 2026
Mirzaee A, Mehrpooya M, Ranjbar A, Naghdi S, Familmotaghi A, Talebi SS, Hosseini SK
Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient's?
pubmed 2026
Dey B, Chatterjee E, Nanda SK, Bansode A, Basak S, Kumar R, Singh H, Doijad N, Wadje BN, Singh PK, Naik PK, Bharate SB, Guru SK
A Thieno[3,2-D] pyrimidine class of p110α/GDH1 dual inhibitor SBS-873 suppresses TNBC growth by inhibiting PI3K/mTOR signaling and inducing ferroptosis through glutathione depletion.
pubmed
Isermann L, Rojas-Morales P, Senft K, Nair N, Baumann L, Croon M, Lauterbach VK, Göbel H, Landini F, Tuma C, Sottorff-Neculhueque I, Thevis M, Ignarski M, Brähler S, Riemer J, Müller RU, Trifunovic A
CLPP loss confers sex-specific protection from renal ischemia reperfusion injury.
pubmed
Gao G, Wang H, Gan L, Wei J, Bi R, Bi B
Effects of black soldier fly larvae meal on hepatic metabolism and intestinal health in juvenile southern catfish (Silurus meridionalis): Insights from non-targeted metabolomics.
pubmed
Zhang X, Du Y, Wu J, Wang F, Kang W, Wei Q, Xu S, Han B
Developmental exposure to amitraz impairs reproductive development and metabolic homeostasis in honey bee (Apis mellifera) queens.
pubmed
Cui J, Jiao Q, Fan L, Alotaibi NM, Liu X, Xu X, Zhou Y, Meng H, Qin S, Cao Y, Chen Y, Agathokleous E, Abou-Elwafa SF, Li G, Jie X, Liu S, Ge C, Liu H
Cadmium tolerance mechanisms and the regulatory role of GST gene in genetically related wheat varieties under Cd stress: A multi-level analysis.
pubmed
Neonatal sepsis (NS) is a life-threatening condition characterized by systemic inflammation in response to infection during the first 28 days of life. Nowadays, it is generally acknowledged that one of the critical pathogenic mechanisms involved in neonatal sepsis is oxidative stress, which plays a critical...
Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis
clinicaltrials 2025
Nutritional derangements are very common in cancer patients and negatively affect survival, morbidity and quality of life. Intervention trials have demonstrated that nutritional counseling can improve energy balance, nutritional status and quality of life in patients undergoing chemo-radiotherapy. Oxidative stress plays a role in the...
Whey Protein Supplementation in Cancer Patients
clinicaltrials 2014
Evaluation of the efficacy of the combined treatment (methimazole plus selenium) in the control of hyperthyroidism as compared to methimazole alone in 30 Graves' disease (GD) untreated patients.
Treatment of Graves' Hyperthyroidism With Selenium Plus Methimazole
clinicaltrials 2015
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
The Evaluation of Balanced Salt Solution During Cataract Surgery
clinicaltrials 2023
This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury. With this trial the investigators are hoping to show the superiority of acetylcysteine (NAC) + fomepizole (4-MP) compared to treatment with...
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
clinicaltrials 2022
This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 4, 8 and week 12.The main questions this study...
The Efficacy of Topical Serum X for Skin Brightening
clinicaltrials 2023
Rationale: Healthcare professionals face a growing burden of responsibilities and work overload which may cause psychological suffering expressed by burnout, depression and other negative psychological variables. Personal behavioral strategies may facilitate the coping process. To maintain these positive characteristics, it is necessary that one decouples...
Meditation Practice in Pediatric Healthcare Professionals
clinicaltrials 2016
Expanded Access (EA) will provide a transition to continue therapy for those patients who are currently in the open label extension of the Phase III study, SL 1009-01, while also allowing new patients diagnosed with PDCD who meet the eligibility criteria to also have access...
Expanded Access Treatment Protocol With DCA for Patients With PDCD
clinicaltrials 2025
Parashar K, Khan MA, Verma M, Pandey P, Thapliyal S, Khan F · Frontiers in oncology
In vivo assessment of broccoli extract based hydrogel in mitigating DMBA induced breast cancer in female mice.
pmc 2026
Chen X, Zhao J, He X, Zhang Y, Wu J, Jiang C, Yang Y, Xiao J · International journal of molecular medicine
Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis.
pmc 2026
Nguyen K, Niu M, Ni HM · Toxicological sciences : an official journal of the Society of Toxicology
Loss of Vacuole Membrane Protein 1 protects against acetaminophen-induced liver injury by modulating inflammation and hepatocyte proliferation.
pmc
Huang X, Ding P, Sun Z, Xiang H, Wei M, Bi H, Zhao Z · Stem cell research & therapy
Lipoaspirate-derived secretome restores redox homeostasis to attenuate pathological scar formation.
pmc
Yu P, Yu S, Yin X, Zhou Z, Chen Y, Zheng X, Ling J, Xia P, Dai Y, Zeng W, Zhang J · Journal of nanobiotechnology
Enzyme-enhanced albumin-stabilized nanopolymers for cascade catalysis-driven ferroptosis-immunotherapy.
pmc
Kebiroğlu MH, Yalcin Azarkan S, Çankaya N · ACS Omega
Multifaceted In Silico and DFT-Based Analysis of 2‑Aminosuccinic Acid on Ferroptosis-Related Targets.
pmc
Kılıç M, Oğuztüzün S, Çelik S, Demirağ F, Bıçakçıoğlu P, İşcan M, Ada AO · Archives of Industrial Hygiene and Toxicology
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma.
pmc 2026
Marcelić L, Malezan L, Vuković K, Katalinić M, Zandona A · Archives of Industrial Hygiene and Toxicology
Fisetin attenuates oxidative and haemolytic damage induced by quinuclidine derivatives in human erythrocytes.
pmc 2026
Pinar Erkekoglu · InTech
Introductory Chapter: A General Overview of Glutathione, Glutathione Transport, and Glutathione Applications
crossref 2018
· CRC Press
Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development
crossref 2006
· American Chemical Society (ACS)
One-Pot Synthesis of Glutathione Trisulfide from Oxidized Glutathione
crossref
· CRC Press
Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides
crossref 2006
Bengt Mannervik, Birgitta Sjödin · CRC Press
Glutathione Transferases
crossref 2018
· American Chemical Society (ACS)
Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors
crossref
Kenneth Curry · CRC Press
Medicinal Chemistry of Glutathione and Glutathione Analogs in the Mammalian Central Nervous System
crossref 2018
· CRC Press
Families of Glutathione Transferases
crossref 2006
William H. Habig, Michael J Pabst, William B. Jakoby · Journal of Biological Chemistry · 18237 citations
Glutathione S-Transferases
openalex 1974
Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry · 47258 citations
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
openalex 2013
Donald E. Paglia, William N. Valentine · PubMed · 10801 citations
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
openalex 1967
Owen W. Griffith · Analytical Biochemistry · 4628 citations
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
openalex 1980
John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther, Anne Barrett Swanson, Dean G. Hafeman, William G. Hoekstra · Science · 7833 citations
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
openalex 1973
Alton Meister, Mary E. Anderson · Annual Review of Biochemistry · 5691 citations
GLUTATHIONE
openalex 1983
M MORON, Joseph William DePierre, Bengt Mannervik · Biochimica et Biophysica Acta (BBA) - General Subjects · 4222 citations
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
openalex 1979
Leopold Flohé, Wolfgang A. Günzler · Methods in enzymology on CD-ROM/Methods in enzymology · 4972 citations
[12] Assays of glutathione peroxidase
openalex 1984
Rai DR, Parveen RS, Nayak V, Kumari S, Bhat VR, Harshini, K. G. MR · Veterinary Medicine International
Ameliorative Role of Ethanolic Nigella sativa Seed Extract in Chlorpyrifos‐Induced Neurotoxicity and Testicular Toxicity.
pmc 2026
Connected data hub
Records with source provenance.
Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.
Regulatory Label
10 recordsopenfdaAdmin reviewed
Nephroplex — Dosage and Administration
DIRECTIONS • 10 drops orally, 3 times a day or as directed by a health care professional. • Consult a physician for use in children under 12 years of age.
openfdaAdmin reviewed
Glutathione — Dosage and Administration
DIRECTIONS: Adults and children 5 to 10 drops orally, 1 time daily or as otherwise directed by a health care professional. If symptoms persist for more than 7 days, consult your health care professional. Consult a physician for...
openfdaAdmin reviewed
Apizelen — Dosage and Administration
DIRECTIONS: • 10 drops orally, 3 times a day or as directed by a health care professional. • Consult a health care professional for use in children under 12 years of age.
openfdaAdmin reviewed
Free Radical — Dosage and Administration
DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.
openfdaAdmin reviewed
Free Radical — Dosage and Administration
DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.
openfdaAdmin reviewed
Kidney Tonic II — Dosage and Administration
DIRECTIONS: • 10 drops orally, 3 times a day or as directed by a health care professional. • Consult a health care professional for use in children under 12 years of age.
openfdaAdmin reviewed
Hepataplex — Dosage and Administration
DIRECTIONS: • 10 drops orally, 3 times a day or as directed by a health care professional. • Consult a health care professional for use in children under 12 years of age.
openfdaAdmin reviewed
FEELSHION Dark Spot Remover Serum — Dosage and Administration
DOSAGE & ADMINISTRATION Use Morning and evening after bath.
openfdaAdmin reviewed
Strength M — Dosage and Administration
DIRECTIONS: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age.
openfdaAdmin reviewed
BSS PLUS — Dosage and Administration
DOSAGE AND ADMINISTRATION The solution should be used according to the standard technique employed by the operating surgeon. Use an administration set with an air-inlet in the plastic spike since the bag does not contain a separate airway...
Clinical Trial
28 recordsclinicaltrialsAdmin reviewed
Comparison Between Topical N-acetyl Cysteine (NAC) in Cold Cream Versus Cold Cream in Mild and Moderate Atopic Dermatitis: Clinical and Bacteriological Evaluation. A Randomized Control Trial.
Atopic dermatitis (AD), or atopic eczema, is a chronic relapsing, inflammatory skin disease, characterized by intense pruritus that leads to considerable burden on patients' quality of life (Sidbury et al., 2023). The dramatic rise of AD prevalence in...
clinicaltrialsAdmin reviewed
Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis
Neonatal sepsis (NS) is a life-threatening condition characterized by systemic inflammation in response to infection during the first 28 days of life. Nowadays, it is generally acknowledged that one of the critical pathogenic mechanisms involved in neonatal sepsis...
clinicaltrialsAdmin reviewed
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
Drug-induced liver injury (DILI) can lead to potentially fatal complications, such as acute liver failure and even death. In clinical practice, glucocorticoids have been considered in some cases of DILI, especially patients with hyperbilirubinemia. However, the available evidence...
clinicaltrialsAdmin reviewed
Expanded Access Treatment Protocol With DCA for Patients With PDCD
Expanded Access (EA) will provide a transition to continue therapy for those patients who are currently in the open label extension of the Phase III study, SL 1009-01, while also allowing new patients diagnosed with PDCD who meet...
clinicaltrialsAdmin reviewed
SPI-1005 for the Treatment of Meniere's Disease (Open Label)
Study of the safety of open-label SPI-1005 400 mg BID treatment in adults with Meniere's Disease (MD) for 6 or 12 months to support chronic or chronic intermittent use.
clinicaltrialsAdmin reviewed
Identification of Serum Level of Glutathione Peroxidase 4
* Analysis of the level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients. * The association of glutathione peroxidase 4 (GPX4) with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis...
clinicaltrialsAdmin reviewed
Streptococcus Salivarius K12@Lip@GSH Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Radiation-induced oral mucositis (RIOM) is the most common oral complication of cancer patients receiving radiotherapy and/or chemotherapy, leading to poor quality of life. the investigators previous studies that have reported the use of single SSK12 probiotics in RIOM....
clinicaltrialsAdmin reviewed
Clinical Analysis of Vitamin B6 in Sepsis
Methodology Patients A total of 128 patients with sepsis and AKI who were admitted to several centers including Huzhou first people's Hospital combined with Wuxing People's Hospital, Linghu people's Hospital and Nanxun people's Hospital from November 1, 2021...
clinicaltrialsAdmin reviewed
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
clinicaltrialsAdmin reviewed
The Efficacy of Topical Serum X for Skin Brightening
This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 4, 8...
clinicaltrialsAdmin reviewed
Dates as a Functional Food for Autism
Autism spectrum disorder (ASD) is a lifelong developmental disability that includes deficits in social communication and social interaction and restricted, repetitive patterns of behavior, interests, or activities. The current treatment approaches for the management of autism are expensive,...
clinicaltrialsAdmin reviewed
A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression
Late-life depression affects 2-8% of seniors and causes high rates of caregiver distress and risk of suicide. To exacerbate the problem, antidepressants, the cornerstone of therapy, are resistant in 55-80% of this population. Hence, this group of patients...
clinicaltrialsAdmin reviewed
36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of 36 weeks short-term optimization treatment of glucocorticosteroid in the patients with chronic recurrent drug-induced liver injury (DILI).
clinicaltrialsAdmin reviewed
Phase IIb Study of Intranasal Glutathione in Parkinson's Disease
Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. Glutathione is an antioxidant made in the body out of three amino acids, the nutrients that make up protein. This...
clinicaltrialsAdmin reviewed
Whey Protein Supplementation in Cancer Patients
Nutritional derangements are very common in cancer patients and negatively affect survival, morbidity and quality of life. Intervention trials have demonstrated that nutritional counseling can improve energy balance, nutritional status and quality of life in patients undergoing chemo-radiotherapy....
clinicaltrialsAdmin reviewed
Methionine Metabolism in Parenterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while synthesis of muscle and structural proteins is decreased. The metabolism...
clinicaltrialsAdmin reviewed
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels
Glutathione is a powerful protective substance found within every cell in the body. It has been shown that glutathione levels go down as a person gets older, which makes a person more likely to get heart disease, high...
clinicaltrialsAdmin reviewed
Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity
Many children with autism have a reduced level of glutathione and a reduced ability to excrete mercury, resulting in elevated levels in their bodies as demonstrated by blood, hair, provoked urine, and baby tooth testing. Our earlier studies...
clinicaltrialsAdmin reviewed
Immune Restoration by Lipoic Acid in AIDS
The purpose of this study is to determine the immunomodulatory and antiviral effects of the glutathione-restoring dithiol, alpha lipoic acid (ALA) in HIV-infected persons unresponsive to highly active antiretroviral treatment (HAART).
clinicaltrialsAutomated import
Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory Models
This preclinical translational study aims to evaluate a new method of delivering lithium using gold nanoparticles for the treatment of bipolar disorder. Lithium is an effective treatment for bipolar disorder, but its clinical use is limited by a...
clinicaltrialsAutomated import
GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry
The goal of the GlycOxiTOD observational registry is to improve the early detection and characterization of vascular and other target-organ damage in adults at increased cardiovascular risk. Target-organ damage (TOD) means changes in the arteries, heart, kidneys, or...
clinicaltrialsAutomated import
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury. With this trial the investigators are hoping to show the superiority of acetylcysteine (NAC)...
clinicaltrialsAutomated import
Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease
The purpose of this study is to assess the efficacy of N-acetylcysteine (NAC) in preventing those with mild or moderate COVID-19 from progressing to severe disease
clinicaltrialsAutomated import
Setria Performance Blend Supplementation
The objective of this trial is to evaluate the effects of setria performance blend supplementation on endurance performance in healthy men.
clinicaltrialsAutomated import
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM). However, its non-glycemic effects are still largely unknown. The...
clinicaltrialsAutomated import
Meditation Practice in Pediatric Healthcare Professionals
Rationale: Healthcare professionals face a growing burden of responsibilities and work overload which may cause psychological suffering expressed by burnout, depression and other negative psychological variables. Personal behavioral strategies may facilitate the coping process. To maintain these positive...
clinicaltrialsAutomated import
Treatment of Graves' Hyperthyroidism With Selenium Plus Methimazole
Evaluation of the efficacy of the combined treatment (methimazole plus selenium) in the control of hyperthyroidism as compared to methimazole alone in 30 Graves' disease (GD) untreated patients.
clinicaltrialsAutomated import
Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation
The study will be conducted as a community-based, randomized, placebo-controlled, trial with four study groups. The overall objective of the study is to determine the optimal method for delivering zinc to young children, both for the prevention of...
Open Access Article
9 recordspmcAutomated import
Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis.
Chen X, Zhao J, He X, Zhang Y, Wu J, Jiang C, Yang Y, Xiao J · International journal of molecular medicine
pmcAutomated import
Ameliorative Role of Ethanolic Nigella sativa Seed Extract in Chlorpyrifos‐Induced Neurotoxicity and Testicular Toxicity.
Rai DR, Parveen RS, Nayak V, Kumari S, Bhat VR, Harshini, K. G. MR · Veterinary Medicine International
pmcAutomated import
In vivo assessment of broccoli extract based hydrogel in mitigating DMBA induced breast cancer in female mice.
Parashar K, Khan MA, Verma M, Pandey P, Thapliyal S, Khan F · Frontiers in oncology
pmcAutomated import
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma.
Kılıç M, Oğuztüzün S, Çelik S, Demirağ F, Bıçakçıoğlu P, İşcan M, Ada AO · Archives of Industrial Hygiene and Toxicology
pmcAutomated import
Fisetin attenuates oxidative and haemolytic damage induced by quinuclidine derivatives in human erythrocytes.
Marcelić L, Malezan L, Vuković K, Katalinić M, Zandona A · Archives of Industrial Hygiene and Toxicology
pmcAutomated import
Loss of Vacuole Membrane Protein 1 protects against acetaminophen-induced liver injury by modulating inflammation and hepatocyte proliferation.
Nguyen K, Niu M, Ni HM · Toxicological sciences : an official journal of the Society of Toxicology
pmcAutomated import
Lipoaspirate-derived secretome restores redox homeostasis to attenuate pathological scar formation.
Huang X, Ding P, Sun Z, Xiang H, Wei M, Bi H, Zhao Z · Stem cell research & therapy
pmcAutomated import
Enzyme-enhanced albumin-stabilized nanopolymers for cascade catalysis-driven ferroptosis-immunotherapy.
Yu P, Yu S, Yin X, Zhou Z, Chen Y, Zheng X, Ling J, Xia P, Dai Y, Zeng W, Zhang J · Journal of nanobiotechnology
pmcAutomated import
Multifaceted In Silico and DFT-Based Analysis of 2‑Aminosuccinic Acid on Ferroptosis-Related Targets.
Kebiroğlu MH, Yalcin Azarkan S, Çankaya N · ACS Omega
Publication
16 recordspubmedAutomated import
Advances in Drug Delivery Systems for Breast Cancer: From Microenvironment Barriers and Smart Carriers to Clinical Translation Strategies.
Liang G, Zhu C, Sun H, Ji Y, Jiang H
pubmedAutomated import
Promising Roles of Selenium Nanoparticles in Anti-Tuberculosis Therapy: Opportunities and Challenges.
Wang Y, Cai J, Kong X, Li J, Ge Y, Zhang Y, Chen Y, Zhu M, Gong H, Zhao D, Pi J
pubmedAutomated import
Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient's?
Mirzaee A, Mehrpooya M, Ranjbar A, Naghdi S, Familmotaghi A, Talebi SS, Hosseini SK
pubmedAutomated import
The association between neonatal respiratory distress syndrome and gut microbiota dysbiosis: evidence from metagenomics.
Liu F, Luo J, Feng L, Xia Y, Chen X, Xu Y, Liu Y
pubmedAutomated import
Salivary Level of Glutathione Reductase, Catalase, and Free Thiol in Patients With Temporomandibular Joint Disorder: A Cross-Sectional Study.
Rezazadeh F, Fassihi N, Mahdavi D, Maroufi S, Khorami ET, Tabesh A, Sedarat H
pubmedAutomated import
Green Synthesis of Silver Nanoparticles From Various Leaves Extract: Antioxidant, Anti-Inflammatory, Antibacterial Activities and Inhibitory Effect on Glutathione S-Transferase.
Sahin Z, Darwich NA, Duran T, Avci D, Silva LR, Sonmez F, Khalil MI
pubmedAutomated import
A Thieno[3,2-D] pyrimidine class of p110α/GDH1 dual inhibitor SBS-873 suppresses TNBC growth by inhibiting PI3K/mTOR signaling and inducing ferroptosis through glutathione depletion.
Dey B, Chatterjee E, Nanda SK, Bansode A, Basak S, Kumar R, Singh H, Doijad N, Wadje BN, Singh PK, Naik PK, Bharate SB, Guru SK
pubmedAutomated import
CLPP loss confers sex-specific protection from renal ischemia reperfusion injury.
Isermann L, Rojas-Morales P, Senft K, Nair N, Baumann L, Croon M, Lauterbach VK, Göbel H, Landini F, Tuma C, Sottorff-Neculhueque I, Thevis M, Ignarski M, Brähler S, Riemer J, Müller RU, Trifunovic A
pubmedAutomated import
Effects of black soldier fly larvae meal on hepatic metabolism and intestinal health in juvenile southern catfish (Silurus meridionalis): Insights from non-targeted metabolomics.
Gao G, Wang H, Gan L, Wei J, Bi R, Bi B
pubmedAutomated import
Developmental exposure to amitraz impairs reproductive development and metabolic homeostasis in honey bee (Apis mellifera) queens.
Zhang X, Du Y, Wu J, Wang F, Kang W, Wei Q, Xu S, Han B
pubmedAutomated import
Cadmium tolerance mechanisms and the regulatory role of GST gene in genetically related wheat varieties under Cd stress: A multi-level analysis.
Cui J, Jiao Q, Fan L, Alotaibi NM, Liu X, Xu X, Zhou Y, Meng H, Qin S, Cao Y, Chen Y, Agathokleous E, Abou-Elwafa SF, Li G, Jie X, Liu S, Ge C, Liu H
pubmedAutomated import
Resveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling.
Hu Y, Wang J, Wang J, Deng Y, Chen W, Zhang Q
pubmedAutomated import
A Covalent Brush-on-Brush Polymer Programs Ordered Intracellular Activation of a Mitochondria-Disrupting Peptide.
Xu R, Ning L, Zhao L, Lu Z, Zhang H, Xu W, Jia F
pubmedAutomated import
Metformin exhibits a synergistic effect with pyrotinib by inducing ferroptosis in HER2-positive cancers through the Keap1/Nrf2 pathway.
Yang Y, Shan G, Li H, Hou J, Wu H, Liu Q, He Y, Zhao S, Ge C, Zhou B, Zhang J, Sun Y, Yang Y
pubmedAutomated import
Cysteine excess triggers a mitochondrial iron-dependent cell death.
Nakamura T, Inoki A, Das NK, Chen B, Khan A, Liu Y, Uygur B, Yen FS, Unlu G, Shah YM, Birsoy K
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A rhamnogalacturonan I-enriched pectic polysaccharide from alfalfa and its protective effects against oxidative stress in Caenorhabditis elegans.
Huang L, Wang H, Liu Y, Wang S, Teng S, Zhang X, Jiang Y, Bahitwa R, Zhao J, Wang Z
Scholarly Work
8 recordscrossrefAutomated import
Introductory Chapter: A General Overview of Glutathione, Glutathione Transport, and Glutathione Applications
Pinar Erkekoglu · InTech
crossrefAutomated import
Medicinal Chemistry of Glutathione and Glutathione Analogs in the Mammalian Central Nervous System
Kenneth Curry · CRC Press
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Glutathione Transferases
Bengt Mannervik, Birgitta Sjödin · CRC Press
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Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development
· CRC Press
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Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides
· CRC Press
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Families of Glutathione Transferases
· CRC Press
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One-Pot Synthesis of Glutathione Trisulfide from Oxidized Glutathione
· American Chemical Society (ACS)
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Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors
· American Chemical Society (ACS)
Article
7 recordsopenalexAutomated import
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry · 47258 citations
openalexAutomated import
GLUTATHIONE
Alton Meister, Mary E. Anderson · Annual Review of Biochemistry · 5691 citations
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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Owen W. Griffith · Analytical Biochemistry · 4628 citations
openalexAutomated import
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
M MORON, Joseph William DePierre, Bengt Mannervik · Biochimica et Biophysica Acta (BBA) - General Subjects · 4222 citations
openalexAutomated import
Glutathione S-Transferases
William H. Habig, Michael J Pabst, William B. Jakoby · Journal of Biological Chemistry · 18237 citations
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther, Anne Barrett Swanson, Dean G. Hafeman, William G. Hoekstra · Science · 7833 citations
openalexAutomated import
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
Donald E. Paglia, William N. Valentine · PubMed · 10801 citations
Book-chapter
1 recordsopenalexAutomated import
[12] Assays of glutathione peroxidase
Leopold Flohé, Wolfgang A. Günzler · Methods in enzymology on CD-ROM/Methods in enzymology · 4972 citations
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