Research context
A peptide studied in reproductive neuroendocrinology and GnRH signalling.
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Reproductive research
Kisspeptin-10
A peptide studied in reproductive neuroendocrinology and GnRH signalling.
30 connected records30 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Barbosa EM, Rodrigues NP, Santos BR, Dos Anjos Cordeiro JM, da Silva TQM, Oliveira CL, Santos LC, Cunha MCDSG, Serakides R, Silva JF
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
pubmed
Netesa MA, Pyurveev SS, Lebedev AA, Bychkov ER, Skorb EV, Shityakov S, Shabanov PD
Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
pubmed 2026
Jaldhi, Kumar S, Shanker OR, Banerjee J, Dixit AB, Maurya SK, Bakshi A
Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.
pubmed
Yeung AC, Phylactou M, Koysombat K, Tsoutsouki J, Nyunt SW, Young M, Patel AH, Daniels E, Pierret ACS, Mills EG, Comninos AN, Abbara A, Dhillo WS
Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.
pubmed
Robert V, Lomet D, Dardente H, Aucagne V, Beltramo M
The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
pubmed 2026
Banerjee AA, Bhanarkar SR, Kashikar S, Keshwani R, Walia S, Kavya DR, Bombe S, Pande S, Modi DN, Pathak BR, Joshi B, Tandon D, Patil A, Begum S, Mahale SD, Rao S, Surve SV
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
pubmed
Shah H, Thomas A, Pandya P
Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.
pubmed 2026
This study utilizes infusions of kisspeptin in healthy women to isolate the impact of kisspeptin on beta-cell responsivity assessed by the mixed meal tolerance test.
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance
clinicaltrials 2020
The present study was designed to assess the responsiveness of the hypothalamic pituitary gonadal axis to kisspeptin administration with increasing age in men.
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men
clinicaltrials 2017
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma LH (luteinizing hormone) and testosterone concentrations.
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
clinicaltrials 2017
The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
clinicaltrials 2022
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin...
KP-10 and Insulin Secretion in Men
clinicaltrials 2018
Spratt JA, Tanday N, McGinn DM, Chukwu CD, Gault VA, Irwin N
Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
pubmed
Spratt JA, Tanday N, McGinn DM, Chukwu CD, Gault VA, Irwin N · Metabolites
Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
pmc 2026
Barbosa EM, Rodrigues NP, Santos BR, Dos Anjos Cordeiro JM, da Silva TQM, Oliveira CL, Santos LC, Cunha MCDSG, Serakides R, Silva JF · Cardiovascular toxicology
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
pmc
Radwańska P, Olkiewicz M, Piera L, Drobnik J · Pharmacological reports : PR
Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.
pmc 2026
Naveed A, Lippincott MF, Stamou M, Balasubramanian R, Bryant NK, Seminara SB · Hormones (Athens, Greece)
Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.
pmc
Gyokova E, Hristova-Atanasova E, Dimitrova K · International journal of molecular sciences
The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.
pmc
Szysiak N, Kosior-Korzecka U, Greguła-Kania M, Patkowski K, Fila M, Junkuszew A · Journal of veterinary research
Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
pmc 2026
Chiang CM, Chiu HY, Chang CS, Chien YY, Jong DS, Wu LS, Chiu CH · Journal of the Chinese Medical Association : JCMA
Role of kisspeptin on cell proliferation and steroidogenesis in luteal cells in vitro and in vivo.
pmc
Santos BR, Dos Anjos Cordeiro JM, Santos LC, Oliveira CS, Alvarez MCPS, Rodrigues NP, Lopez-Tello J, Sferruzzi-Perri AN, Serakides R, Silva JF · Acta physiologica (Oxford, England)
Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
pmc 2026
· ECO-Vector LLC (Publications)
Fig. 1. Number of runs between arms in the elevated plus maze test. Intact — intact group of mice without any treatment; Sat. r. VB — intraperitoneal administration of 0.9% sodium chloride solution; Sat. r. IN — intranasal administration of 0.9% sodium chloride solution; Kisspeptin IN 0.1 — intranasal administration of kisspeptin-10 at a dosage of 0.1 μg; Kisspeptin IN 1 — intranasal administration of kisspeptin-10 at a dosage of 1 μg; Kisspeptin IN 10 — intranasal administration of kisspeptin-10 at a dosage of 10 μg; Kisspeptin VB 1 — intraperitoneal administration of kisspeptin-10 at a dosage of 1 μg; Kisspeptin VB 10 — intraperitoneal administration of kisspeptin-10 at a dosage of 10 μg; Kisspeptin VB 100 — intraperitoneal administration of kisspeptin-10 at a dosage of 100 μg. *p <0.05; **p <0.01 — differences between intact and experimental animals.
crossref
· ECO-Vector LLC (Publications)
Fig. 1. Number of arm entries in the elevated plus maze. Intact, intact group of animals without intervention; NaCl IP, intraperitoneal administration of 0.9% sodium chloride solution; NaCl IN, intranasal administration of 0.9% sodium chloride solution; kisspeptin 0.1 IN, intranasal administration of kisspeptin-10 at a dose of 0.1 µg; kisspeptin 1 IN, intranasal administration of kisspeptin-10 at a dose of 1 µg; kisspeptin 10 IN, intranasal administration of kisspeptin-10 at a dose of 10 µg; kisspeptin 1 IP, intraperitoneal administration of kisspeptin-10 at a dose of 1 µg; kisspeptin 10 IP, intraperitoneal administration of kisspeptin-10 at a dose of 10 µg; kisspeptin 100 IP, intraperitoneal administration of kisspeptin-10 at a dose of 100 µg.*р < 0.05; **р < 0.01, differences between intact and experimental animals.
crossref
· ECO-Vector LLC (Publications)
Fig. 1. Animal behavior in the sexual motivation test following intraperitoneal (i.p.) injection of 0.9% sodium chloride solution and kisspeptin-10: a, latency period; b, number of approaches to the female. 1, intact (intact group of animals without intervention); 2, i.p. kisspeptin 1 (intraperitoneal injection of kisspeptin-10 at a dose of 1 µg); 3, i.p. kisspeptin 10 (intraperitoneal injection of kisspeptin-10 at a dose of 10 µg); 4, i.p. kisspeptin 100 (intraperitoneal injection of kisspeptin-10 at a dose of 100 µg); 5, i.p. saline (intraperitoneal injection of 0.9% sodium chloride solution). Data are presented as M ± m. *p ≤ 0.05, difference between the kisspeptin-10 group and the intact group.
crossref
Svaty Sachania, Naushin Nawar, Aaron Ghelut, Waljit Dhillo, Kim C Jonas · Bioscientifica
Are all kisspeptins equal? The effect of kisspeptin 10 and kisspeptin 54 on kisspeptin-mediated signalling
crossref 2019
· American Chemical Society (ACS)
Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor
crossref
Elena Schmidt · University Goettingen Repository
Kisspeptin-10 - ein potenzieller Inhibitor der Invasion humaner Endometriumkarzinomzellen
crossref
· ECO-Vector LLC (Publications)
Fig. 2. Number of mounts per female. 1, means intact controls; 2, means restraint stress without drug introduction; 3, means restraint stress + kisspeptin-10 intranasally (single introduction); 4, means restraint stress + kisspeptin-10 intraperitoneally (single introduction); 5, means restraint stress + kisspeptin-10 intranasally (5-day introduction course); 6, means restraint stress + kisspeptin-10 intraperitoneally (5-day introduction course). ##p < 0.01 relative to animal group exposed to restraint stress; ***p < 0.001 relative to intact controls.
crossref
· ECO-Vector LLC (Publications)
Fig. 1. Effect of intranasal and intraperitoneal administration of kisspeptin-10 on the level of gonadotropin-releasing hormone in the hypothalamus of animals with posttraumatic stress disorder induced by restraint stress or vital stress. Here and in Figs. 2 and 3: 1, intact control; 2, restraint stress; 3, restraint stress + kisspeptin-10 intranasal (5-day treatment course); 4, restraint stress + kisspeptin-10 intraperitoneal (5-day treatment course); 5, vital stress; 6, vital stress + kisspeptin-10 intranasal (5-day treatment course); 7, vital stress + kisspeptin-10 intraperitoneal (5-day treatment course). *p = 0.0468 vs. the intact control group; #p = 0.0246 vs. the restraint stress group; $p = 0.0002 vs. the vital stress group.
crossref
Mazzarino M, Colpaert T, Deventer K, Van Eenoo P
Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.
pubmed
Connected data hub
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Clinical Trial
5 recordsclinicaltrialsAdmin reviewed
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp
clinicaltrialsAdmin reviewed
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance
This study utilizes infusions of kisspeptin in healthy women to isolate the impact of kisspeptin on beta-cell responsivity assessed by the mixed meal tolerance test.
clinicaltrialsAdmin reviewed
KP-10 and Insulin Secretion in Men
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to...
clinicaltrialsAdmin reviewed
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men
The present study was designed to assess the responsiveness of the hypothalamic pituitary gonadal axis to kisspeptin administration with increasing age in men.
clinicaltrialsAdmin reviewed
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma LH (luteinizing...
Publication
9 recordspubmedAutomated import
The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
Robert V, Lomet D, Dardente H, Aucagne V, Beltramo M
pubmedAutomated import
Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
Netesa MA, Pyurveev SS, Lebedev AA, Bychkov ER, Skorb EV, Shityakov S, Shabanov PD
pubmedAutomated import
Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.
Shah H, Thomas A, Pandya P
pubmedAutomated import
Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
Spratt JA, Tanday N, McGinn DM, Chukwu CD, Gault VA, Irwin N
pubmedAutomated import
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
Barbosa EM, Rodrigues NP, Santos BR, Dos Anjos Cordeiro JM, da Silva TQM, Oliveira CL, Santos LC, Cunha MCDSG, Serakides R, Silva JF
pubmedAutomated import
Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.
Jaldhi, Kumar S, Shanker OR, Banerjee J, Dixit AB, Maurya SK, Bakshi A
pubmedAutomated import
Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.
Yeung AC, Phylactou M, Koysombat K, Tsoutsouki J, Nyunt SW, Young M, Patel AH, Daniels E, Pierret ACS, Mills EG, Comninos AN, Abbara A, Dhillo WS
pubmedAutomated import
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
Banerjee AA, Bhanarkar SR, Kashikar S, Keshwani R, Walia S, Kavya DR, Bombe S, Pande S, Modi DN, Pathak BR, Joshi B, Tandon D, Patil A, Begum S, Mahale SD, Rao S, Surve SV
pubmedAutomated import
Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.
Mazzarino M, Colpaert T, Deventer K, Van Eenoo P
Open Access Article
8 recordspmcAutomated import
Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
Spratt JA, Tanday N, McGinn DM, Chukwu CD, Gault VA, Irwin N · Metabolites
pmcAutomated import
Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.
Radwańska P, Olkiewicz M, Piera L, Drobnik J · Pharmacological reports : PR
pmcAutomated import
Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
Santos BR, Dos Anjos Cordeiro JM, Santos LC, Oliveira CS, Alvarez MCPS, Rodrigues NP, Lopez-Tello J, Sferruzzi-Perri AN, Serakides R, Silva JF · Acta physiologica (Oxford, England)
pmcAutomated import
Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
Szysiak N, Kosior-Korzecka U, Greguła-Kania M, Patkowski K, Fila M, Junkuszew A · Journal of veterinary research
pmcAutomated import
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
Barbosa EM, Rodrigues NP, Santos BR, Dos Anjos Cordeiro JM, da Silva TQM, Oliveira CL, Santos LC, Cunha MCDSG, Serakides R, Silva JF · Cardiovascular toxicology
pmcAutomated import
Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.
Naveed A, Lippincott MF, Stamou M, Balasubramanian R, Bryant NK, Seminara SB · Hormones (Athens, Greece)
pmcAutomated import
The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.
Gyokova E, Hristova-Atanasova E, Dimitrova K · International journal of molecular sciences
pmcAutomated import
Role of kisspeptin on cell proliferation and steroidogenesis in luteal cells in vitro and in vivo.
Chiang CM, Chiu HY, Chang CS, Chien YY, Jong DS, Wu LS, Chiu CH · Journal of the Chinese Medical Association : JCMA
Scholarly Work
8 recordscrossrefAutomated import
Are all kisspeptins equal? The effect of kisspeptin 10 and kisspeptin 54 on kisspeptin-mediated signalling
Svaty Sachania, Naushin Nawar, Aaron Ghelut, Waljit Dhillo, Kim C Jonas · Bioscientifica
crossrefAutomated import
Fig. 1. Number of runs between arms in the elevated plus maze test. Intact — intact group of mice without any treatment; Sat. r. VB — intraperitoneal administration of 0.9% sodium chloride solution; Sat. r. IN — intranasal administration of 0.9% sodium chloride solution; Kisspeptin IN 0.1 — intranasal administration of kisspeptin-10 at a dosage of 0.1 μg; Kisspeptin IN 1 — intranasal administration of kisspeptin-10 at a dosage of 1 μg; Kisspeptin IN 10 — intranasal administration of kisspeptin-10 at a dosage of 10 μg; Kisspeptin VB 1 — intraperitoneal administration of kisspeptin-10 at a dosage of 1 μg; Kisspeptin VB 10 — intraperitoneal administration of kisspeptin-10 at a dosage of 10 μg; Kisspeptin VB 100 — intraperitoneal administration of kisspeptin-10 at a dosage of 100 μg. *p <0.05; **p <0.01 — differences between intact and experimental animals.
· ECO-Vector LLC (Publications)
crossrefAutomated import
Fig. 1. Number of arm entries in the elevated plus maze. Intact, intact group of animals without intervention; NaCl IP, intraperitoneal administration of 0.9% sodium chloride solution; NaCl IN, intranasal administration of 0.9% sodium chloride solution; kisspeptin 0.1 IN, intranasal administration of kisspeptin-10 at a dose of 0.1 µg; kisspeptin 1 IN, intranasal administration of kisspeptin-10 at a dose of 1 µg; kisspeptin 10 IN, intranasal administration of kisspeptin-10 at a dose of 10 µg; kisspeptin 1 IP, intraperitoneal administration of kisspeptin-10 at a dose of 1 µg; kisspeptin 10 IP, intraperitoneal administration of kisspeptin-10 at a dose of 10 µg; kisspeptin 100 IP, intraperitoneal administration of kisspeptin-10 at a dose of 100 µg.*р < 0.05; **р < 0.01, differences between intact and experimental animals.
· ECO-Vector LLC (Publications)
crossrefAutomated import
Fig. 1. Animal behavior in the sexual motivation test following intraperitoneal (i.p.) injection of 0.9% sodium chloride solution and kisspeptin-10: a, latency period; b, number of approaches to the female. 1, intact (intact group of animals without intervention); 2, i.p. kisspeptin 1 (intraperitoneal injection of kisspeptin-10 at a dose of 1 µg); 3, i.p. kisspeptin 10 (intraperitoneal injection of kisspeptin-10 at a dose of 10 µg); 4, i.p. kisspeptin 100 (intraperitoneal injection of kisspeptin-10 at a dose of 100 µg); 5, i.p. saline (intraperitoneal injection of 0.9% sodium chloride solution). Data are presented as M ± m. *p ≤ 0.05, difference between the kisspeptin-10 group and the intact group.
· ECO-Vector LLC (Publications)
crossrefAutomated import
Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor
· American Chemical Society (ACS)
crossrefAutomated import
Kisspeptin-10 - ein potenzieller Inhibitor der Invasion humaner Endometriumkarzinomzellen
Elena Schmidt · University Goettingen Repository
crossrefAutomated import
Fig. 2. Number of mounts per female. 1, means intact controls; 2, means restraint stress without drug introduction; 3, means restraint stress + kisspeptin-10 intranasally (single introduction); 4, means restraint stress + kisspeptin-10 intraperitoneally (single introduction); 5, means restraint stress + kisspeptin-10 intranasally (5-day introduction course); 6, means restraint stress + kisspeptin-10 intraperitoneally (5-day introduction course). ##p < 0.01 relative to animal group exposed to restraint stress; ***p < 0.001 relative to intact controls.
· ECO-Vector LLC (Publications)
crossrefAutomated import
Fig. 1. Effect of intranasal and intraperitoneal administration of kisspeptin-10 on the level of gonadotropin-releasing hormone in the hypothalamus of animals with posttraumatic stress disorder induced by restraint stress or vital stress. Here and in Figs. 2 and 3: 1, intact control; 2, restraint stress; 3, restraint stress + kisspeptin-10 intranasal (5-day treatment course); 4, restraint stress + kisspeptin-10 intraperitoneal (5-day treatment course); 5, vital stress; 6, vital stress + kisspeptin-10 intranasal (5-day treatment course); 7, vital stress + kisspeptin-10 intraperitoneal (5-day treatment course). *p = 0.0468 vs. the intact control group; #p = 0.0246 vs. the restraint stress group; $p = 0.0002 vs. the vital stress group.
· ECO-Vector LLC (Publications)
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Recent PubMed records
Regulation of PACAP gene expression by ovarian sex steroids and kisspeptin: Study using hypothalamic cell lines and an in vivo female rat model.PMID 42936012 · 2026 DecKisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis.PMID 42871171 · 2026 DecKisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling.PMID 42806235 · 2026 Sep 28Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.PMID 42783811 · 2026 Sep 17Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.PMID 42726152 · 2026 Sep 11Registered clinical studies
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal ToleranceNCT04532801 · WITHDRAWNLink Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.NCT03286517 · COMPLETEDAge-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in MenNCT03315325 · COMPLETEDResponsible use of information
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