Research context
An unapproved synthetic melanocortin analogue used in laboratory research.
Regulatory note: Verify local laws, product approval and professional guidance before any human use. This profile is not a recommendation for use.
Melanocortin research
Melanotan II
An unapproved synthetic melanocortin analogue used in laboratory research.
34 connected records34 graded citations0 external identifiers
Evidence map
Claims linked to original records.
Evidence levels describe study design. They do not by themselves establish safety or effectiveness.
Robert T. Dorr, Ruskin R. Lines, Norman S. Levine, Christine A. Brooks, Li Xiang, Victor J. Hruby et al. · Life Sciences · 135 citations
Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
openalex 1996
M. Kilpeläinen, Juha Mönkäre, Maria A. Vlasova, Joakim Riikonen, Vesa‐Pekka Lehto, Jarno Salonen et al. · European Journal of Pharmaceutics and Biopharmaceutics · 64 citations
Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery
openalex 2010
Kasper Fjellhaugen Hjuler, Henrik Frank Lorentzen · Dermatology · 31 citations
Melanoma Associated with the Use of Melanotan-II
openalex 2013
Michael E. Nelson, Sean M. Bryant, Steven E. Aks · Clinical Toxicology · 34 citations
Melanotan II injection resulting in systemic toxicity and rhabdomyolysis
openalex 2012
Annemieke C. Heijboer, Anita M. van den Hoek, Hanno Pijl, Peter J. Voshol, Louis M. Havekes, Johannes Anthonius Romijn et al. · Diabetologia · 43 citations
Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
openalex 2005
Anne‐Sophie Rössler, James G. Pfaus, Hossein Kami Kia, J. Bernabé, L Alexandre, François Giuliano · Pharmacology Biochemistry and Behavior · 44 citations
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat
openalex 2006
Torben Breindahl, Michael J. Evans-Brown, Peter Hindersson, Jim McVeigh, Mark A Bellis, Allan Stensballe et al. · Drug Testing and Analysis · 34 citations
Identification and characterization by LC‐UV‐MS/MS of melanotan II skin‐tanning products sold illegally on the Internet
openalex 2014
Weirath NA, Haskell-Luevano C
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).
pubmed
· American Chemical Society (ACS)
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
crossref
· American Chemical Society (ACS)
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
crossref
· American Chemical Society (ACS)
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
crossref
&NA; · Springer Science and Business Media LLC
Melanotan II
crossref 2012
· Springer Science and Business Media LLC
Melanotan-II
crossref 2015
Bonchev A
Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.
pubmed
Yassin Alsabbagh A, Bhujel N, Singh RP
Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?
pubmed 2025
Inozemtseva LS, Yatsenko KA, Glazova NY, Kamensky AA, Myasoedov NF, Levitskaya NG, Grivennikov IA, Dolotov OV
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
pubmed
Deville M, Charlier C
Barbie drug identification: Not a child's play.
pubmed 2024
Liu H, Liu Z, Wong HK, Xu N, Liu Q, Li Y, Liu Y, Wong H, Burt ME, Jossy SV, Han J, He Y
Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.
pubmed
Castro G, Mendes NF, Weissmann L, Quaresma PGF, Saad MJA, Prada PO
Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.
pubmed
Todorovic M, Blanc A, Wang Z, Lozada J, Froelich J, Zeisler J, Zhang C, Merkens H, Benard F, Perrin DM
5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2'-bis-Indole Peptide Staples: Application to Melanotan-II.
pubmed
This example interventional study record describes a randomized Phase 2 clinical trial evaluating investigational Melanotan II (MT-II) as an adjunct to standard NB-UVB phototherapy for repigmentation in adults with stable nonsegmental vitiligo.
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo
clinicaltrials 2026
Grant B, Kean J, de Silva NL, Aguilera R, Quinton OCB, Gumssani M, Bassett P, Dhillo WS, Lingford-Hughes A, Wolff K, Jayasena CN · The Journal of clinical endocrinology and metabolism
Clinical features of androgen abuse withdrawal in men during the first year of cessation: a community dwelling study.
pmc
Resnick G, Khajeh-Afzaly M, Yousefian F, Raza A, Issa NT · The Journal of clinical and aesthetic dermatology
Insights into Tanning Biology and Tanning Products.
pmc 2026
Liu H, Liu Z, Wong HK, Xu N, Liu Q, Li Y, Liu Y, Wong H, Burt ME, Jossy SV, Han J, He Y · Endocrinology
Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.
pmc
Bonchev A · Life (Basel, Switzerland)
Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.
pmc
Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL · Hypertension (Dallas, Tex. : 1979)
Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence.
pmc 2024
Côté I, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ · Canadian journal of physiology and pharmacology
Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
pmc 2018
Weirath NA, Haskell-Luevano C · ACS pharmacology & translational science
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).
pmc
· Springer Science and Business Media LLC
Melanotan ii
crossref 2026
&NA; · Springer Science and Business Media LLC
Melanotan II
crossref 2012
&NA; · Springer Science and Business Media LLC
Melanotan II overdose
crossref 2012
Hunter Wessells, Norman S. Levine, M E Hadley, R T Dorr, Victor J. Hruby · International Journal of Impotence Research · 118 citations
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II
openalex 2000
Moiz A, O'Keefe EL, O'Keefe JH
Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
pubmed
Moiz A, O'Keefe EL, O'Keefe JH · Missouri medicine
Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
pmc
Connected data hub
Records with source provenance.
Reviewed records carry an admin-reviewed badge. Automated records link back to the provider for independent checking.
Clinical Trial
1 recordsclinicaltrialsAdmin reviewed
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo
This example interventional study record describes a randomized Phase 2 clinical trial evaluating investigational Melanotan II (MT-II) as an adjunct to standard NB-UVB phototherapy for repigmentation in adults with stable nonsegmental vitiligo.
Scholarly Work
8 recordscrossrefAutomated import
Melanotan ii
· Springer Science and Business Media LLC
crossrefAutomated import
Melanotan-II
· Springer Science and Business Media LLC
crossrefAutomated import
Melanotan II
&NA; · Springer Science and Business Media LLC
crossrefAutomated import
Melanotan II overdose
&NA; · Springer Science and Business Media LLC
crossrefAutomated import
Melanotan II
&NA; · Springer Science and Business Media LLC
crossrefAutomated import
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
· American Chemical Society (ACS)
crossrefAutomated import
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
· American Chemical Society (ACS)
crossrefAutomated import
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
· American Chemical Society (ACS)
Open Access Article
8 recordspmcAutomated import
Insights into Tanning Biology and Tanning Products.
Resnick G, Khajeh-Afzaly M, Yousefian F, Raza A, Issa NT · The Journal of clinical and aesthetic dermatology
pmcAutomated import
Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence.
Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL · Hypertension (Dallas, Tex. : 1979)
pmcAutomated import
Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
Côté I, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ · Canadian journal of physiology and pharmacology
pmcAutomated import
Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
Moiz A, O'Keefe EL, O'Keefe JH · Missouri medicine
pmcAutomated import
Clinical features of androgen abuse withdrawal in men during the first year of cessation: a community dwelling study.
Grant B, Kean J, de Silva NL, Aguilera R, Quinton OCB, Gumssani M, Bassett P, Dhillo WS, Lingford-Hughes A, Wolff K, Jayasena CN · The Journal of clinical endocrinology and metabolism
pmcAutomated import
Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.
Liu H, Liu Z, Wong HK, Xu N, Liu Q, Li Y, Liu Y, Wong H, Burt ME, Jossy SV, Han J, He Y · Endocrinology
pmcAutomated import
Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.
Bonchev A · Life (Basel, Switzerland)
pmcAutomated import
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).
Weirath NA, Haskell-Luevano C · ACS pharmacology & translational science
Publication
9 recordspubmedAutomated import
Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?
Yassin Alsabbagh A, Bhujel N, Singh RP
pubmedAutomated import
Barbie drug identification: Not a child's play.
Deville M, Charlier C
pubmedAutomated import
Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.
Bonchev A
pubmedAutomated import
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
Inozemtseva LS, Yatsenko KA, Glazova NY, Kamensky AA, Myasoedov NF, Levitskaya NG, Grivennikov IA, Dolotov OV
pubmedAutomated import
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).
Weirath NA, Haskell-Luevano C
pubmedAutomated import
Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.
Liu H, Liu Z, Wong HK, Xu N, Liu Q, Li Y, Liu Y, Wong H, Burt ME, Jossy SV, Han J, He Y
pubmedAutomated import
Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.
Castro G, Mendes NF, Weissmann L, Quaresma PGF, Saad MJA, Prada PO
pubmedAutomated import
Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
Moiz A, O'Keefe EL, O'Keefe JH
pubmedAutomated import
5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2'-bis-Indole Peptide Staples: Application to Melanotan-II.
Todorovic M, Blanc A, Wang Z, Lozada J, Froelich J, Zeisler J, Zhang C, Merkens H, Benard F, Perrin DM
Article
8 recordsopenalexAutomated import
Identification and characterization by LC‐UV‐MS/MS of melanotan II skin‐tanning products sold illegally on the Internet
Torben Breindahl, Michael J. Evans-Brown, Peter Hindersson, Jim McVeigh, Mark A Bellis, Allan Stensballe et al. · Drug Testing and Analysis · 34 citations
openalexAutomated import
Melanoma Associated with the Use of Melanotan-II
Kasper Fjellhaugen Hjuler, Henrik Frank Lorentzen · Dermatology · 31 citations
openalexAutomated import
Melanotan II injection resulting in systemic toxicity and rhabdomyolysis
Michael E. Nelson, Sean M. Bryant, Steven E. Aks · Clinical Toxicology · 34 citations
openalexAutomated import
Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery
M. Kilpeläinen, Juha Mönkäre, Maria A. Vlasova, Joakim Riikonen, Vesa‐Pekka Lehto, Jarno Salonen et al. · European Journal of Pharmaceutics and Biopharmaceutics · 64 citations
openalexAutomated import
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat
Anne‐Sophie Rössler, James G. Pfaus, Hossein Kami Kia, J. Bernabé, L Alexandre, François Giuliano · Pharmacology Biochemistry and Behavior · 44 citations
openalexAutomated import
Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
Annemieke C. Heijboer, Anita M. van den Hoek, Hanno Pijl, Peter J. Voshol, Louis M. Havekes, Johannes Anthonius Romijn et al. · Diabetologia · 43 citations
openalexAutomated import
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II
Hunter Wessells, Norman S. Levine, M E Hadley, R T Dorr, Victor J. Hruby · International Journal of Impotence Research · 118 citations
openalexAutomated import
Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
Robert T. Dorr, Ruskin R. Lines, Norman S. Levine, Christine A. Brooks, Li Xiang, Victor J. Hruby et al. · Life Sciences · 135 citations
Live discovery
Latest research signals
Live results from PubMed, ClinicalTrials.gov and UniProt. These may not yet have been reviewed or stored in the Data Hub.
Recent PubMed records
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.PMID 42862021 · 2026 Sep 30Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.PMID 42757290 · 2026 Jul-AugChanges in Oral Mucosa Associated with Melanotan II Injections: A Case Report.PMID 41752902 · 2026 Feb 3Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?PMID 40210573 · 2025 SepAntidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.PMID 39442746 · 2024 Dec 5Registered clinical studies
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoNCT07437560 · RECRUITINGReviewed UniProt records
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